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Tytuł:
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Sample preparation strategies for the determination of psychoactive substances in biological fluids.
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Autorzy:
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Esteve-Turrillas FA; Department of Analytical Chemistry, University of Valencia, Jerónimo Muñoz Building, 50th Dr. Moliner St., 46100 Burjassot, Spain. Electronic address: .
Armenta S; Department of Analytical Chemistry, University of Valencia, Jerónimo Muñoz Building, 50th Dr. Moliner St., 46100 Burjassot, Spain.
de la Guardia M; Department of Analytical Chemistry, University of Valencia, Jerónimo Muñoz Building, 50th Dr. Moliner St., 46100 Burjassot, Spain.
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Źródło:
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Journal of chromatography. A [J Chromatogr A] 2020 Dec 06; Vol. 1633, pp. 461615. Date of Electronic Publication: 2020 Oct 14.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam ; New York : Elsevier, 1993-
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MeSH Terms:
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Body Fluids/*chemistry
Clinical Chemistry Tests/*methods
Psychotropic Drugs/*analysis
Chromatography ; Clinical Chemistry Tests/standards ; Clinical Chemistry Tests/trends ; Humans ; Liquid Phase Microextraction ; Liquid-Liquid Extraction ; Psychotropic Drugs/blood ; Psychotropic Drugs/urine ; Saliva/chemistry ; Solid Phase Extraction ; Solid Phase Microextraction ; Specimen Handling/standards
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Contributed Indexing:
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Keywords: Biological fluids; Liquid chromatography-mass spectrometry; Microextraction; New psychoactive substances; Solid-phase extraction
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Substance Nomenclature:
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0 (Psychotropic Drugs)
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Entry Date(s):
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Date Created: 20201025 Date Completed: 20201124 Latest Revision: 20201124
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Update Code:
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20240105
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DOI:
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10.1016/j.chroma.2020.461615
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PMID:
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33099196
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This review focuses on the existing analytical procedures for the determination of new psychoactive substances (NPS) in biological fluids by chromatographic methods. Direct analysis of samples is scarcely employed and most proposed methodologies include a sample pre-treatment in order to remove matrix interferents and, in some cases, pre-concentrate extracts. Current extraction methods for NPS determination in plasma/serum, urine, and oral fluids have been widely discussed, such as liquid-liquid, solid-phase, and micro extraction approaches, highlighting the advantages and drawbacks of the proposed extraction methodologies. Regarding microextraction approaches, techniques like microextraction by packed sorbent, solid-phase microextraction, miniaturized solid phase extraction, and dispersive liquid-liquid extraction have been proposed for NPS determination in biological fluids with reliable analytical results.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
