Angioedema: A potential complication of dupilumab in atopic dermatitis.

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Tytuł:: Angioedema: A potential complication of dupilumab in atopic dermatitis.
Autorzy:: Fritz AL; Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA.
Lacy FA; Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA.
Morrell DS; Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA.
Źródło:: Pediatric dermatology [Pediatr Dermatol] 2021 Jan; Vol. 38 (1), pp. 237-238. Date of Electronic Publication: 2020 Oct 25.
Typ publikacji:: Case Reports
Język:: English
Imprint Name(s):: Publication: <2010->: Hoboken, NJ : Wiley
Original Publication: [Boston, MA] : Blackwell Scientific Publications, [1983-
MeSH Terms:: Angioedema*/chemically induced
Angioedema*/drug therapy
Dermatitis, Atopic*/drug therapy
Eczema*
Antibodies, Monoclonal, Humanized/adverse effects ; Child ; Female ; Humans
References:: Simpson EL, Paller AS, Siegfried EC, et al. Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitis: A phase 3 randomized clinical trial. JAMA Dermatol. 2020;156(1):44-56. https://doi.org/10.1001/jamadermatol.2019.3336.
Simpson EL, Bieber T, Guttman-Yassky E, et al. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Eng J Med. 2016;375(24):2335-2348. https://doi.org/10.1056/NEJMoa1610020.
Hahn J, Hoffmann TK, Bock B, Nordmann-Kleiner M, Trainotti S, Greve J. Angioedema. Dtsch Arztebl Int. 2017;114(29-30):489-496. https://doi.org/10.3238/arztebl.2017.0489.
Zhu GA, Chen JK, Chiou A, Ko J, Honari G. Assessment of the development of new regional dermatoses in patients treated for atopic dermatitis With dupilumab. JAMA Dermatol. 2019;155(7):850-852. https://doi.org/10.1001/jamadermatol.2019.0109.
Albader SS, Alharbi AA, Alenezi RF, Alsaif FM. Dupilumab side effect in a patient with atopic dermatitis: a case report study. Biologics. 2019;13:79-82. https://doi.org/10.2147/BTT.S195512.
Soria A, Du-Thanh A, Seneschal J, Jachiet M, Staumont-Sallé D, Barbarot S. Development or Exacerbation of head and neck dermatitis in patients treated for atopic dermatitis with dupilumab. JAMA Dermatol. 2019;155(11):1312-1315. https://doi.org/10.1001/jamadermatol.2019.2613.
Contributed Indexing:: Keywords: angioedema; atopic dermatitis; biologic; drug reaction; dupilumab
Substance Nomenclature:: 0 (Antibodies, Monoclonal, Humanized)
420K487FSG (dupilumab)
Entry Date(s):: Date Created: 20201025 Date Completed: 20210514 Latest Revision: 20210514
Update Code:: 20240105
DOI:: 10.1111/pde.14434
PMID:: 33099796
: Raport

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Dupilumab is a relatively new and quite effective medication for recalcitrant atopic dermatitis in patients over 6 years of age. Here, we present a 12-year-old girl with progressively worsening episodic facial swelling and erythema while treated with dupilumab. This case highlights the possibility of angioedema as an adverse effect of dupilumab treatment.
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