The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway.

Szczegóły
Abstrakt

Tytuł:: The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway.
Autorzy:: Hao Q; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Zong X; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Sun Q; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Lin YC; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Song YJ; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Hashemikhabir S; Department of BioHealth Informatics, School of Informatics and Computing, IUPUI, Indianapolis, United States.
Hsu RY; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Kamran M; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Chaudhary R; Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
Tripathi V; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Singh DK; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Chakraborty A; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Li XL; Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
Kim YJ; Department of Biological Sciences and Center for Systems Biology, The University of Texas at Dallas, Richardson, United States.
Orjalo AV; LGC Biosearch Technologies, Petaluma, United States.
Polycarpou-Schwarz M; Division of RNA Biology and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Moriarity BS; Department of Pediatrics, University of Minnesota, Minneapolis, United States.
Jenkins LM; Center for Cancer Research National Cancer Institute, Bethesda, United States.
Johansson HE; LGC Biosearch Technologies, Petaluma, United States.
Zhu YJ; Molecular Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
Diederichs S; Division of RNA Biology and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Cancer University of Freiburg, German Cancer Consortium (DKTK), Freiburg, Germany.
Bagchi A; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States.
Kim TH; Department of Biological Sciences and Center for Systems Biology, The University of Texas at Dallas, Richardson, United States.
Janga SC; Department of BioHealth Informatics, School of Informatics and Computing, IUPUI, Indianapolis, United States.
Lal A; Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
Prasanth SG; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Prasanth KV; Department of Cell and Developmental Biology, Cancer center at Illinois, University of Illinois at Urbana-Champaign, Urbana, United States.
Źródło:: ELife [Elife] 2020 Oct 27; Vol. 9. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
MeSH Terms:: Gene Expression Regulation*
Cell Proliferation/*genetics
Co-Repressor Proteins/*genetics
Cytoskeletal Proteins/*genetics
DEAD-box RNA Helicases/*genetics
RNA, Long Noncoding/*genetics
Signal Transduction/*physiology
Co-Repressor Proteins/metabolism ; Cytoskeletal Proteins/metabolism ; DEAD-box RNA Helicases/metabolism ; HCT116 Cells ; HeLa Cells ; Humans ; RNA, Long Noncoding/metabolism ; S Phase ; Up-Regulation
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Grant Information:: GM088252 United States GM NIGMS NIH HHS; R01 CA200643 United States CA NCI NIH HHS; R01 GM132458 United States GM NIGMS NIH HHS; R21 AG065748 United States AG NIA NIH HHS; GM125196 United States GM NIGMS NIH HHS; GM123314 United States GM NIGMS NIH HHS; RSG-11-174-01-RMC International American Cancer Society; R01 GM088252 United States GM NIGMS NIH HHS; 1243372 International National Science Foundation; 1723008 International National Science Foundation; R01 GM123314 United States GM NIGMS NIH HHS; AG065748 United States AG NIA NIH HHS; R01 GM125196 United States GM NIGMS NIH HHS; 1818286 International National Science Foundation
Contributed Indexing:: Keywords: HCT116; U2OS; WTIP; cell cycle; chromosomes; gene expression; human cancer cell lines; lncRNA; none
Molecular Sequence:: GEO GSE143275; GSE157393
Substance Nomenclature:: 0 (Co-Repressor Proteins)
0 (Cytoskeletal Proteins)
0 (RNA, Long Noncoding)
0 (WTIP protein, human)
EC 3.6.1.- (Ddx5 protein, human)
EC 3.6.4.13 (DEAD-box RNA Helicases)
Entry Date(s):: Date Created: 20201027 Date Completed: 20210223 Latest Revision: 20211029
Update Code:: 20240105
PubMed Central ID:: PMC7591261
DOI:: 10.7554/eLife.55102
PMID:: 33108271
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Cell cycle is a cellular process that is subject to stringent control. In contrast to the wealth of knowledge of proteins controlling the cell cycle, very little is known about the molecular role of lncRNAs (long noncoding RNAs) in cell-cycle progression. By performing genome-wide transcriptome analyses in cell-cycle-synchronized cells, we observed cell-cycle phase-specific induction of >2000 lncRNAs. Further, we demonstrate that an S-phase-upregulated lncRNA, SUNO1 , facilitates cell-cycle progression by promoting YAP1-mediated gene expression. SUNO1 facilitates the cell-cycle-specific transcription of WTIP , a positive regulator of YAP1, by promoting the co-activator, DDX5-mediated stabilization of RNA polymerase II on chromatin. Finally, elevated SUNO1 levels are associated with poor cancer prognosis and tumorigenicity, implying its pro-survival role. Thus, we demonstrate the role of a S-phase up-regulated lncRNA in cell-cycle progression via modulating the expression of genes controlling cell proliferation.
Competing Interests: QH, XZ, QS, YL, YS, SH, RH, MK, RC, VT, DS, AC, XL, YK, MP, BM, LJ, YZ, SD, AB, TK, SJ, SP, KP No competing interests declared, AO Arturo V Orjalo is affiliated with LGC Biosearch Technologies and Genentech Inc, the author has no financial interests to declare, HJ Hans Johansson is affiliated with LGC Biosearch Technologies. The author has no financial interests to declare. AL Reviewing editor, eLife

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