Two years into the Brazilian Reproducibility Initiative: reflections on conducting a large-scale replication of Brazilian biomedical science.

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Tytuł:: Two years into the Brazilian Reproducibility Initiative: reflections on conducting a large-scale replication of Brazilian biomedical science.
Autorzy:: Neves K; Universidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica Leopoldo de Meis, Rio de Janeiro, RJ, Brasil.
Carneiro CF; Universidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica Leopoldo de Meis, Rio de Janeiro, RJ, Brasil.
Wasilewska-Sampaio AP; Universidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica Leopoldo de Meis, Rio de Janeiro, RJ, Brasil.
Abreu M; Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, RJ, Brasil.
Valério-Gomes B; Universidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica Leopoldo de Meis, Rio de Janeiro, RJ, Brasil.
Tan PB; Universidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica Leopoldo de Meis, Rio de Janeiro, RJ, Brasil.
Amaral OB; Universidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica Leopoldo de Meis, Rio de Janeiro, RJ, Brasil.
Źródło:: Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2020 Oct 23; Vol. 115, pp. e200328. Date of Electronic Publication: 2020 Oct 23 (Print Publication: 2020).
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Rio de Janeiro : Instituto Oswaldo Cruz
MeSH Terms:: Research Design*
Biomedical Research/*trends
Brazil ; Reproducibility of Results
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Entry Date(s):: Date Created: 20201028 Date Completed: 20201029 Latest Revision: 20201104
Update Code:: 20240105
PubMed Central ID:: PMC7586442
DOI:: 10.1590/0074-02760200328
PMID:: 33111750
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Scientists have increasingly recognised that low methodological and analytical rigour combined with publish-or-perish incentives can make the published scientific literature unreliable. As a response to this, large-scale systematic replications of the literature have emerged as a way to assess the problem empirically. The Brazilian Reproducibility Initiative is one such effort, aimed at estimating the reproducibility of Brazilian biomedical research. Its goal is to perform multicentre replications of a quasi-random sample of at least 60 experiments from Brazilian articles published over a 20-year period, using a set of common laboratory methods. In this article, we describe the challenges of managing a multicentre project with collaborating teams across the country, as well as its successes and failures over the first two years. We end with a brief discussion of the Initiative's current status and its possible future contributions after the project is concluded in 2021.

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