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Tytuł pozycji:

Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters.

Tytuł :
Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters.
Autorzy :
Ben Taleb A; Faculty of Engineering, Department of Bio and Nanotechnology, Istanbul University-Cerrahpasa, Istanbul, Turkey. .
Karakuş S; Faculty of Engineering, Department of Bio and Nanotechnology, Istanbul University-Cerrahpasa, Istanbul, Turkey.; Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Tan E; Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Ilgar M; Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Kutlu Ö; Nanotechnology Research andApplication Center (SUNUM),Sabanci University, Istanbul, Turkey.
Gözüaçık D; Koç University Hospital, School of Medicine and Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Zeytinburnu 34010, Istanbul, Turkey.
Kutlu HM; Department of Biology, Faculty of Science, Eskişehir Technical University, Eskişehir, Turkey.
Kilislioğlu A; Faculty of Engineering, Department of Bio and Nanotechnology, Istanbul University-Cerrahpasa, Istanbul, Turkey.; Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Pokaż więcej
Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2207, pp. 199-220.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: Totowa, NJ : Humana Press
Original Publication: Clifton, N.J. : Humana Press,
MeSH Terms :
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacokinetics
Antineoplastic Agents*/pharmacology
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Drug Carriers*/pharmacology
Neoplasms*/drug therapy
Neoplasms*/metabolism
Neoplasms*/pathology
Quinolones*/chemistry
Quinolones*/pharmacokinetics
Quinolones*/pharmacology
Polyethylene Glycols/*chemistry
Resins, Plant/*chemistry
HeLa Cells ; Humans
Contributed Indexing :
Keywords: Anticancer*; Ceranib-2*; Nanoencapsulation*; PEGylation*; Rosin ester*
Substance Nomenclature :
0 (3-(3-(4-methoxyphenyl)acryloyl)-4-phenyl-1H-quinolin-2-one)
0 (Antineoplastic Agents)
0 (Drug Carriers)
0 (Quinolones)
0 (Resins, Plant)
3WJQ0SDW1A (Polyethylene Glycols)
88S87KL877 (rosin)
B697894SGQ (polyethylene glycol 400)
Entry Date(s) :
Date Created: 20201028 Date Completed: 20210324 Latest Revision: 20210324
Update Code :
20210325
DOI :
10.1007/978-1-0716-0920-0_16
PMID :
33113138
Czasopismo naukowe
Ceranib-2 is a recently discovered, poorly water-soluble potent ceramidase inhibitor, with the ability to suppress cancer cell proliferation and delay tumor growth. However, its poor water solubility and weak cellular bioavailability hinder its use as a therapeutic agent for cancer. PEGylated rosin esters are an excellent platform as a natural polymer for drug delivery applications, especially for controlling drug release due to their degradability, biocompatibility, capability to improve solubility, and pharmacokinetics of potent drugs. In this study, stable aqueous amphiphilic submicron-sized PEG400-rosin ester-ceranib-2 (PREC-2) particles, ranging between 100 and 350 nm in a 1:1 mixture, were successfully synthesized by solvent evaporation mediated by sonication.Conclusion: Stable aqueous PEGylated rosin ester nanocarriers might present a significant solution to improve solubility, pharmacokinetic, and bioavailability of ceranib-2, and hold promises for use as an anticancer adjacent drug after further investigations.

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