Post-transplantation cyclophosphamide versus antithymocyte globulin in patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation from HLA-identical sibling donors: A retrospective analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. - OpacWWW

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Tytuł:: Post-transplantation cyclophosphamide versus antithymocyte globulin in patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation from HLA-identical sibling donors: A retrospective analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.
Autorzy:: Battipaglia G; Hematology Department, Hôpital Saint Antoine, Service d'Hématologie et Thérapie Cellulaire, Paris, France.; Hematology Department, Federico II University, Naples, Italy.
Labopin M; Hematology Department, Hôpital Saint Antoine, Service d'Hématologie et Thérapie Cellulaire, Paris, France.; Acute Leukemia Working Party of EBMT, Paris, France.; Hospital Saint-Antoine, Sorbonne University, INSERM U938, Paris, France.
Hamladji RM; Centre Pierre et Marie Curie, Service Hématologie Greffe de Moëlle, Alger, Algeria.
Blaise D; Programme de Transplantation & Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France.
Chevallier P; CHU Nantes, Department D'Hematologie, Nantes, France.
Brissot E; Hematology Department, Hôpital Saint Antoine, Service d'Hématologie et Thérapie Cellulaire, Paris, France.; Hospital Saint-Antoine, Sorbonne University, INSERM U938, Paris, France.
Gerbitz A; Charité Universitaetsmedizin Berlin, Campus Virchow Klinikum, Medizinische Klinik m. S. Hämatologie/Onkologie, Berlin, Germany.
Socié G; Department of Hematology-BMT, Hopital St. Louis, Paris, France.
Afanasyev B; First State Pavlov Medical University of St. Petersburg, Raisa Gorbacheva Memorial Research Institute for Paediatric Oncology, Hematology, and Transplantation, St. Petersburg, Russia.
Ciceri F; Ospedale San Raffaele s.r.l., Haematology and BMT, Milano, Italy.
Meijer E; Department of Hematology (Br 250), VU University Medical Center, Amsterdam, Netherlands.
Koc Y; Medical Park Hospitals, Stem Cell Transplant Unit, Antalya, Turkey.
Cornelissen JJ; Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Huynh A; CHU-Institut Universitaire du Cancer Toulouse, Oncopole, Toulouse, France.
Ozdogu H; Haematology Division, BMT Unit, Haematology Research Laboratory, Baskent University Hospital, Adana, Turkey.
Maertens J; Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium.
Paul F; Département d`Hématologie Clinique, CHU Lapeyronie, Montpellier, France.
Labussière-Wallet H; Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre Bénite, France.
Ruggeri A; Ospedale San Raffaele s.r.l., Haematology and BMT, Milano, Italy.
Aljurf M; Oncology Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Bazarbachi A; Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Savani B; Division of Hematology/Oncology, Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Nagler A; Acute Leukemia Working Party of EBMT, Paris, France.; Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Mohty M; Hematology Department, Hôpital Saint Antoine, Service d'Hématologie et Thérapie Cellulaire, Paris, France.; Acute Leukemia Working Party of EBMT, Paris, France.; Hospital Saint-Antoine, Sorbonne University, INSERM U938, Paris, France.
Źródło:: Cancer [Cancer] 2021 Jan 15; Vol. 127 (2), pp. 209-218. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji:: Comparative Study; Journal Article
Język:: English
Imprint Name(s):: Publication: <2005- >: Hoboken, NJ : Wiley
Original Publication: New York [etc.] Published for the American Cancer Society by J. Wiley [etc.]
MeSH Terms:: Blood Donors*
Siblings*
Antilymphocyte Serum/*administration & dosage
Cyclophosphamide/*administration & dosage
Graft vs Host Disease/*prevention & control
HLA Antigens/*immunology
Hematopoietic Stem Cell Transplantation/*adverse effects
Hematopoietic Stem Cell Transplantation/*methods
Immunosuppressive Agents/*administration & dosage
Leukemia, Myeloid, Acute/*surgery
Adolescent ; Adult ; Aged ; Feasibility Studies ; Female ; Follow-Up Studies ; Graft vs Host Disease/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Transplantation, Homologous/methods ; Treatment Outcome ; Young Adult
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Contributed Indexing:: Keywords: acute myeloid leukemia; allogeneic hematopoietic transplantation; antithymocyte globulin; graft-versus-host disease; post-transplantation cyclophosphamide
Substance Nomenclature:: 0 (Antilymphocyte Serum)
0 (HLA Antigens)
0 (Immunosuppressive Agents)
8N3DW7272P (Cyclophosphamide)
Entry Date(s):: Date Created: 20201029 Date Completed: 20210827 Latest Revision: 20210827
Update Code:: 20240105
DOI:: 10.1002/cncr.33255
PMID:: 33119152
: Czasopismo naukowe

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Background: Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Addition of antithymocyte globulin (ATG) or post-transplantation cyclophosphamide (PTCY) to standard immunosuppressive agents reduces GVHD in different donor settings.
Methods: We compared the outcomes of adults with acute myeloid leukemia undergoing allo-HSCT from HLA-identical sibling donors after the use of PTCY (n = 197) or ATG (n = 1913).
Results: Patients in the PTCY group were younger than those in the ATG group (median age, 47 vs 54 years; P < .01). Peripheral blood was the most frequently used stem cell source, being significantly more frequent in the ATG group than in the PTCY group (95% vs 70% P < .01). The conditioning regimen was more frequently myeloablative in the PTCY group than in the ATG group (59% vs 48%; P < .01). Time to neutrophil engraftment was shorter in the ATG group than in the PTCY group (17 vs 20 days; P < .01). No differences were observed according to the other transplantation outcomes, except for chronic GVHD of all grades and extensive chronic GVHD at 2 years, which were significantly lower in the ATG group compared with the PTCY group (P < .02).
Conclusion: PTCY is feasible in an HLA-identical sibling setting, and despite similar outcomes, ATG may be associated with lower incidence of chronic GVHD.
(© 2020 American Cancer Society.)

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