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Tytuł pozycji:

Oral chronic graft-versus-host disease: What the general dental practitioner needs to know.

Tytuł:
Oral chronic graft-versus-host disease: What the general dental practitioner needs to know.
Autorzy:
Haverman TM
Raber-Durlacher JE
Raghoebar II
Rademacher WMH
Rozema FR
Hazenberg MD
Epstein JB
Treister NS
Źródło:
Journal of the American Dental Association (1939) [J Am Dent Assoc] 2020 Nov; Vol. 151 (11), pp. 846-856.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 2015- : London : Elsevier
Original Publication: Chicago, Ill. : American Dental Association, c1939-
MeSH Terms:
Graft vs Host Disease*/diagnosis
Graft vs Host Disease*/etiology
Hematopoietic Stem Cell Transplantation*/adverse effects
Chronic Disease ; Dentists ; Humans ; Professional Role
Contributed Indexing:
Keywords: Oral graft-versus-host-disease; caries; dental treatment; hematopoietic stem cell transplantation; hyposalivation; oral candidiasis; oral care; trismus; xerostomia
Entry Date(s):
Date Created: 20201030 Date Completed: 20201111 Latest Revision: 20201111
Update Code:
20240105
DOI:
10.1016/j.adaj.2020.08.001
PMID:
33121606
Czasopismo naukowe
Background: Long-term survivors of allogeneic hematopoietic cell transplantation will increasingly seek care from dental providers.
Methods: The authors highlight the importance of minimizing oral symptoms and complications associated with oral chronic graft-versus-host-disease (cGVHD).
Results: Chronic GVHD is the result of an immune response of donor-derived cells against recipient tissues. Oral cGVHD can affect the mucosa and damage salivary glands and cause sclerotic changes. Symptoms include sensitivity and pain, dry mouth, taste changes, and limited mouth opening. Risk of developing caries and oral cancer is increased. Food intake, oral hygiene, and dental interventions can represent challenges. Oral cGVHD manifestations and dental interventions should be managed in close consultation with the medical team, as systemic treatment for cGVHD can have implications for dental management.
Conclusions: General dental practitioners can contribute substantially to alleviating oral cGVHD involvement and preventing additional oral health deterioration.
Practical Implications: Frequent examinations, patient education, oral hygiene reinforcement, dry mouth management, caries prevention, and management of dental needs are indicated. In addition, oral physical therapy might be needed. Invasive dental interventions should be coordinated with the transplantation team. Screening for oral malignancies is important even years after resolution of GVHD symptoms. Management of the oral manifestations of cGVHD might require referral to an oral medicine professional.
(Copyright © 2020 American Dental Association. Published by Elsevier Inc. All rights reserved.)

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