COVID-19: a potential driver of immune-mediated breast cancer recurrence?

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Tytuł:: COVID-19: a potential driver of immune-mediated breast cancer recurrence?
Autorzy:: Francescangeli F; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
De Angelis ML; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Zeuner A; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. .
Źródło:: Breast cancer research : BCR [Breast Cancer Res] 2020 Oct 30; Vol. 22 (1), pp. 117. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: London, UK : BioMed Central Ltd
Original Publication: London, UK : Current Science, c1999-
MeSH Terms:: Breast Neoplasms/*immunology
Breast Neoplasms/*virology
Coronavirus Infections/*immunology
Neoplasm Recurrence, Local/*immunology
Neoplasm Recurrence, Local/*virology
Pneumonia, Viral/*immunology
Betacoronavirus/immunology ; Breast Neoplasms/pathology ; COVID-19 ; Coronavirus Infections/virology ; Extracellular Traps/immunology ; Female ; Humans ; Lung/immunology ; Lung/pathology ; Neoplasm Recurrence, Local/pathology ; Neutrophils/immunology ; Pandemics ; Pneumonia/immunology ; Pneumonia/virology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Tumor Microenvironment/immunology
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Blood. 2020 Sep 3;136(10):1169-1179. (PMID: 32597954)
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Grant Information:: AIRC IG 20744 International Associazione Italiana per la Ricerca sul Cancro
Contributed Indexing:: Keywords: Breast cancer; COVID-19; Disseminated tumor cells; Dormancy; Inflammation; Metastasis; Metastatic reawakening; Relapse; Tumor recurrence
Entry Date(s):: Date Created: 20201031 Date Completed: 20201113 Latest Revision: 20201218
Update Code:: 20240105
PubMed Central ID:: PMC7598231
DOI:: 10.1186/s13058-020-01360-0
PMID:: 33126915
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Severe coronavirus disease 2019 (COVID-19) causes a hyperactivation of immune cells, resulting in lung inflammation. Recent studies showed that COVID-19 induces the production of factors previously implicated in the reawakening of dormant breast cancer cells such as neutrophil extracellular traps (NETs). The presence of NETs and of a pro-inflammatory microenvironment may therefore promote breast cancer reactivation, increasing the risk of pulmonary metastasis. Further studies will be required to confirm the link between COVID-19 and cancer recurrence. However, an increased awareness on the potential risks for breast cancer patients with COVID-19 may lead to improved treatment strategies to prevent metastatic relapse.

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