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Tytuł:
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Participation of Ghanaian pregnant women in an antimalarial drug trial: willingness, experiences and perceptions.
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Autorzy:
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Osarfo J; Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Adjei RO; Department of Health Education, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Magnussen P; Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Tagbor HK; Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
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Źródło:
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Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2021 Jun 02; Vol. 115 (6), pp. 714-719.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2013- : Oxford : Oxford University Press
Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene
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MeSH Terms:
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Antimalarials*/therapeutic use
HIV Infections*
Female ; Ghana ; Humans ; Male ; Perception ; Pregnancy ; Pregnant Women ; Qualitative Research
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References:
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Grant Information:
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United Kingdom WT_ Wellcome Trust
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Contributed Indexing:
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Keywords: Ghana; clinical trials; experiences; perceptions; pregnant women; willingness
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Substance Nomenclature:
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0 (Antimalarials)
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Entry Date(s):
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Date Created: 20201102 Date Completed: 20210624 Latest Revision: 20240216
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Update Code:
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20240216
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PubMed Central ID:
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PMC8169309
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DOI:
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10.1093/trstmh/traa120
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PMID:
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33137818
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Background: With increasing orientation towards including pregnant women in clinical trials, investigators must conduct culturally acceptable research to aid recruitment and retention. There is limited information on experiences and meanings that pregnant women make of trial participation in Africa. This study reports experiences and perceptions of Ghanaian pregnant women regarding their participation in a clinical trial.
Methods: From October to December 2012, 45 in-depth interviews were conducted among pregnant women and their male partners regarding their experiences and perceptions of clinical trial processes as part of an antimalarial drug safety and efficacy trial in pregnant women in the Ashanti region of Ghana. Analysis was by predetermined themes and inductive analysis.
Results: Familiarity with the disease studied in the trial and trust in health workers favoured participation with the latter underlying acceptance of study drugs in the absence of symptoms. Adverse drug events were perceived as intrinsic sickness exhibited on the path to wellness. There were no cultural barriers to blood sampling during home visits but hospital-based sampling was preferred. Home visits were linked to participants having HIV infection.
Conclusion: This study contributes knowledge on sociocultural matters underpinning pregnant women's decisions regarding trial participation in an era of increasing drug trials involving pregnant women.
(© The Author(s) 2020. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)