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Tytuł pozycji:

Telomere Length and Hematological Disorders: A Review.

Tytuł :
Telomere Length and Hematological Disorders: A Review.
Autorzy :
Nogueira BMD; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Machado CB; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Montenegro RC; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
DE Moraes MEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Moreira-Nunes CA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil .
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Źródło :
In vivo (Athens, Greece) [In Vivo] 2020 Nov-Dec; Vol. 34 (6), pp. 3093-3101.
Typ publikacji :
Journal Article; Review
Język :
English
Imprint Name(s) :
Original Publication: Athens : Dr. J.G. Delinassios
Contributed Indexing :
Keywords: Telomere length; cancer; hematological disorders; review
Entry Date(s) :
Date Created: 20201104 Latest Revision: 20201104
Update Code :
20201218
DOI :
10.21873/invivo.12142
PMID :
33144412
Czasopismo naukowe
Telomeres compose the end portions of human chromosomes, and their main function is to protect the genome. In hematological disorders, telomeres are shortened, predisposing to genetic instability that may cause DNA damage and chromosomal rearrangements, inducing a poor clinical outcome. Studies from 2010 to 2019 were compiled and experimental studies using samples of patients diagnosed with hematological malignancies that reported the size of the telomeres were described. Abnormal telomere shortening is described in cancer, but in hematological neoplasms, telomeres are still shortened even after telomerase reactivation. In this study, we compared the sizes of telomeres in leukemias, myelodysplastic syndrome and lymphomas, identifying that the smallest telomeres are present in patients at relapse. In conclusion, the experimental and clinical data analyzed in this review demonstrate that excessive telomere shortening is present in major hematological malignancies and its analysis and measurement is a crucial step in determining patient prognosis, predicting disease risk and assisting in the decision for targeted therapeutic strategies.
(Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

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