Sea buckthorn (Hippophae rhamnoides L.) fermentation liquid protects against alcoholic liver disease linked to regulation of liver metabolome and the abundance of gut microbiota.

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Tytuł:: Sea buckthorn (Hippophae rhamnoides L.) fermentation liquid protects against alcoholic liver disease linked to regulation of liver metabolome and the abundance of gut microbiota.
Autorzy:: Ran B; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, PR China.
Guo CE; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, PR China.; Engineering Research Center of Good Agricultural Practice for Chinese Crude Drugs, Ministry of Education, Beijing, P. R. China.
Li W; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, PR China.; Engineering Research Center of Good Agricultural Practice for Chinese Crude Drugs, Ministry of Education, Beijing, P. R. China.
Li W; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, PR China.
Wang Q; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, PR China.
Qian J; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, PR China.
Li H; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, PR China.
Źródło:: Journal of the science of food and agriculture [J Sci Food Agric] 2021 May; Vol. 101 (7), pp. 2846-2854. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons
Original Publication: London, Society of Chemical Industry.
MeSH Terms:: Gastrointestinal Microbiome*
Fermented Foods/*analysis
Fruit and Vegetable Juices/*analysis
Hippophae/*metabolism
Liver/*metabolism
Liver Diseases, Alcoholic/*diet therapy
Animals ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Endostatins ; Feces/microbiology ; Fermentation ; Fruit/chemistry ; Fruit/metabolism ; Fruit/microbiology ; Fruit and Vegetable Juices/microbiology ; Hippophae/chemistry ; Hippophae/microbiology ; Humans ; Lactobacillus plantarum/metabolism ; Liver Diseases, Alcoholic/metabolism ; Liver Diseases, Alcoholic/microbiology ; Male ; Mice ; Peptide Fragments
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Contributed Indexing:: Keywords: Hepatoprotective; alcoholic liver disease; fermentation liquid; gut microbiota; oxidative stress; sea buckthorn
Substance Nomenclature:: 0 (AP25 peptide)
0 (Endostatins)
0 (Peptide Fragments)
Entry Date(s):: Date Created: 20201104 Date Completed: 20210420 Latest Revision: 20211204
Update Code:: 20240105
DOI:: 10.1002/jsfa.10915
PMID:: 33145761
: Czasopismo naukowe

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Background: Alcoholic liver disease (ALD) refers to liver damage caused by long-term heavy drinking, which causes oxidative stress and changes in gut microbiota. In this paper, we investigated the hepatoprotective effect of sea buckthorn fermentation liquid on ALD in mice and the interaction between ALD and gut microbiota using animal experiments and gut microbiota measurements.
Results: We found that the contents of total flavonoids, total triterpenes and related short-chain fatty acids (SCFAs) in sea buckthorn fermentation liquid (SFL) were significantly greater. Liver index, kidney index, spleen index, serum indexes of liver injury - alanine aminotransferase (ALT) and spartate aminotransferase (AST), inflammatory factors in liver tissues - tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), oxidation indexes - malondialdehyde (MDA) and superoxide dismutase (SOD), and lipid metabolism indexes - high-density liptein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and triglyceride (TG), suggested that SFL significantly ameliorates liver injury caused by alcohol. By measuring gut microbiota in mice feces samples, we found that the high-dose group of SFL reversed the declining trend of the gut microbiota Firmicutes/Bacteroidetes (F/B) ratio caused by alcohol, reducing the number of gram-negative bacteroidetes. Patescibacteria was tightly connected with the indicators of ALD. At the genus level, high-dose SFL significantly downregulated Akkermansia, Turicibacter, Alistipes and Ruminiclostridium, and improved the abundance of beneficial bacteria in Lactobacillus. In addition, Alistipes and Ruminiclostridium was closely connected with the indicators of ALD.
Conclusion: Sea buckthorn fermentation liquid protected against alcoholic liver disease and modulated the composition of gut microbiota. © 2020 Society of Chemical Industry.
(© 2020 Society of Chemical Industry.)

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