Characteristics of depressed suicide attempters with remitted substance use disorders.

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Abstrakt

Tytuł:: Characteristics of depressed suicide attempters with remitted substance use disorders.
Autorzy:: Rizk MM; Department of Psychiatry, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: .
Galfalvy H; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Miller JM; Department of Psychiatry, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Milak M; Department of Psychiatry, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Parsey R; Department of Psychiatry, Stony Brook University, New York, NY, USA.
Grunebaum M; Department of Psychiatry, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Burke A; Department of Psychiatry, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Sublette ME; Department of Psychiatry, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Oquendo MA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Stanley B; Department of Psychiatry, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Mann JJ; Department of Psychiatry, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA.
Źródło:: Journal of psychiatric research [J Psychiatr Res] 2021 May; Vol. 137, pp. 572-578. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Oxford : Pergamon Press
MeSH Terms:: Substance-Related Disorders*/epidemiology
Suicide, Attempted*
Aggression ; Female ; Humans ; Impulsive Behavior ; Male ; Personality Disorders ; Risk Factors ; Suicidal Ideation
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Grant Information:: R01 MH040695 United States MH NIMH NIH HHS; R01 MH096784 United States MH NIMH NIH HHS; P50 MH062185 United States MH NIMH NIH HHS; K23 MH076049 United States MH NIMH NIH HHS; K08 MH085061 United States MH NIMH NIH HHS; R01 MH074813 United States MH NIMH NIH HHS; R01 MH093637 United States MH NIMH NIH HHS; P50 MH090964 United States MH NIMH NIH HHS; R21 MH091553 United States MH NIMH NIH HHS; K08 MH079033 United States MH NIMH NIH HHS
Contributed Indexing:: Keywords: Impulsivity/aggression; Mood disorder; Substance use disorder; Suicide
Entry Date(s):: Date Created: 20201107 Date Completed: 20210520 Latest Revision: 20220503
Update Code:: 20240105
PubMed Central ID:: PMC8084874
DOI:: 10.1016/j.jpsychires.2020.10.041
PMID:: 33158553
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Substance use disorder (SUD) comorbidity in mood disorders increases suicide risk. Suicide attempters with active SUD appear to have distinct characteristics but little is known whether these characteristics persist during remission and if they are related to different aspects of suicidal behavior. In this study, suicide attempters with a DSM mood disorder and remitted SUD (AT+SUD) (N = 135) were compared to those without lifetime SUD (AT-SUD) (N = 219) in terms of demographic, clinical and suicidal behavioral characteristics. Factor analyses were conducted to generate subjective distress and impulsivity/aggression factors - previously identified by our group to predict suicide risk in mood disorders. Associations between these traits and SUD history and suicidal behavior characteristics were then tested. Compared with AT-SUD, AT+SUD were more likely to be male, less educated and to have a Cluster B personality disorder. AT+SUD individuals had greater impulsivity/aggression factor scores, but comparable subjective distress scores. AT+SUD made a greater number of suicide attempts, with higher lethality, despite comparable suicide intent and degree of planning with AT-SUD. Impulsivity/aggression was higher in multiple versus single attempters, but did not correlate with suicide attempt lethality. Among suicide attempters with mood disorders, a history of lifetime SUD was associated with more frequent and more lethal suicide attempts. Among other correlates of lifetime SUD in this sample, impulsive/aggressive traits may explain greater frequency of suicide attempts. The results underscore that persons with mood disorders and lifetime SUD are at particularly high risk of frequent and lethal suicide attempts where more intensive prevention efforts are warranted.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)

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