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Tytuł pozycji:

Abnormalities in evoked potentials associated with abnormal glycemia and brain injury in neonatal hypoxic-ischemic encephalopathy.

Tytuł :
Abnormalities in evoked potentials associated with abnormal glycemia and brain injury in neonatal hypoxic-ischemic encephalopathy.
Autorzy :
Kamino D; The Hospital for Sick Children and University of Toronto, Department of Pediatrics (Division of Neurology), Toronto, ON M5G 1X8, Canada.
Almazrooei A; The Hospital for Sick Children and University of Toronto, Department of Pediatrics (Division of Neurology), Toronto, ON M5G 1X8, Canada.
Pang EW; The Hospital for Sick Children and University of Toronto, Department of Pediatrics (Division of Neurology), Toronto, ON M5G 1X8, Canada; Neurosciences and Mental Health, SickKids Research Institute, Toronto, ON M5G 0A4, Canada.
Widjaja E; Neurosciences and Mental Health, SickKids Research Institute, Toronto, ON M5G 0A4, Canada; The Hospital for Sick Children and University of Toronto, Department of Diagnostic Imaging, Toronto, ON M5G 1X8, Canada.
Moore AM; The Hospital for Sick Children and University of Toronto, Department of Pediatrics (Division of Neonatology), Toronto, ON M5G 1X8, Canada.
Chau V; The Hospital for Sick Children and University of Toronto, Department of Pediatrics (Division of Neurology), Toronto, ON M5G 1X8, Canada; Neurosciences and Mental Health, SickKids Research Institute, Toronto, ON M5G 0A4, Canada.
Tam EWY; The Hospital for Sick Children and University of Toronto, Department of Pediatrics (Division of Neurology), Toronto, ON M5G 1X8, Canada; Neurosciences and Mental Health, SickKids Research Institute, Toronto, ON M5G 0A4, Canada. Electronic address: .
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Źródło :
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2021 Jan; Vol. 132 (1), pp. 307-313. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Amsterdam : Elsevier, c1999-
Contributed Indexing :
Keywords: Hyperglycemia; Hypoglycemia; Hypoxic ischemic encephalopathy (HIE); Magnetic resonance imaging (MRI); Somatosensory evoked potentials; Visual evoked potentials
Entry Date(s) :
Date Created: 20201107 Latest Revision: 20210111
Update Code :
20210111
DOI :
10.1016/j.clinph.2020.09.024
PMID :
33158762
Czasopismo naukowe
Objective: To investigate how functional integrity of ascending sensory pathways measured by visual and somatosensory evoked potentials (VEP & SEP) is associated with abnormal glycemia and brain injury in newborns treated with hypothermia for hypoxic-ischemic encephalopathy (HIE).
Methods: Fifty-four neonates ≥ 36 weeks gestational age with HIE underwent glucose testing, VEPs, SEPs, and magnetic resonance imaging (MRI) the first week of life. Minimum and maximum glucose values recorded prior to evoked potential (EP) testing were compared with VEP and SEP measures using generalized estimating equations. Relationships between VEP and SEP measures and brain injury on MRI were assessed.
Results: Maximum glucose is associated with decreased P200 amplitude, and increased odds that N300 peak will be delayed/absent. Minimum glucose is associated with decreased P22 amplitude. Presence of P200 and N300 peaks is associated with decreased odds of brain injury in the visual processing pathway, with delayed/absent N300 peak associated with increased odds of brain injury in posterior white matter.
Conclusions: Deviations from normoglycemia are associated with abnormal EPs, and abnormal VEPs are associated with brain injury on MRI in cooled neonates with HIE.
Significance: Glucose is a modifiable risk factor associated with atypical brain function in neonates with HIE despite hypothermia treatment.
(Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)

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