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Tytuł pozycji:

Vanishing washout of hepatocellular carcinoma according to the presence of hepatic steatosis: diagnostic performance of CT and MRI.

Tytuł :
Vanishing washout of hepatocellular carcinoma according to the presence of hepatic steatosis: diagnostic performance of CT and MRI.
Autorzy :
Min JH; Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, South Korea.
Kang TW; Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, South Korea. .
Kim YY; Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, South Korea.; Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Cha DI; Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, South Korea.
Kim YK; Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, South Korea.
Kim SH; Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, South Korea.
Sinn DH; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Ha SY; Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Kim K; Biostatics and Clinical Epidemiology Center, Samsung Medical Center, Seoul, South Korea.
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Źródło :
European radiology [Eur Radiol] 2021 May; Vol. 31 (5), pp. 3315-3325. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Berlin : Springer International, c1991-
MeSH Terms :
Carcinoma, Hepatocellular*/complications
Carcinoma, Hepatocellular*/diagnostic imaging
Fatty Liver*/complications
Fatty Liver*/diagnostic imaging
Liver Neoplasms*/diagnostic imaging
Contrast Media ; Gadolinium DTPA ; Humans ; Magnetic Resonance Imaging ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed
References :
European Association for the Study of the Liver (2018) EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 69:182–236.
Marrero JA, Kulik LM, Sirlin CB et al (2018) Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases. Hepatology 68:723–750. (PMID: 10.1002/hep.29913)
Heimbach JK, Kulik LM, Finn RS et al (2018) AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology 67:358–380. (PMID: 10.1002/hep.29086)
Korean Liver Cancer Association (KLCA); National Cancer Center (NCC), Goyang, Korea (2019) 2018 Korean Liver Cancer Association-National Cancer Center Korea practice guidelines for the management of hepatocellular carcinoma. Korean J Radiol 20:1042–1113.
Omata M, Cheng AL, Kokudo N et al (2017) Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatol Int 11:317–370. (PMID: 10.1007/s12072-017-9799-9)
Santillan C, Fowler K, Kono Y, Chernyak V (2018) LI-RADS major features: CT, MRI with extracellular agents, and MRI with hepatobiliary agents. Abdom Radiol (NY) 43:75–81. (PMID: 10.1007/s00261-017-1291-4)
Tang A, Bashir MR, Corwin MT et al (2018) Evidence supporting LI-RADS major features for CT- and MR imaging-based diagnosis of hepatocellular carcinoma: a systematic review. Radiology 286:29–48. (PMID: 10.1148/radiol.2017170554)
Kitzing YX, Ng BH, Kitzing B et al (2015) Washout of hepatocellular carcinoma on portal venous phase of multidetector computed tomography in a pre-transplant population. J Med Imaging Radiat Oncol 59:673–680. (PMID: 10.1111/1754-9485.12347)
Min JH, Kim JM, Kim YK et al (2018) Prospective intraindividual comparison of magnetic resonance imaging with gadoxetic acid and extracellular contrast for diagnosis of hepatocellular carcinomas using the Liver Imaging Reporting and Data System. Hepatology 68:2254–2266. (PMID: 10.1002/hep.30122)
Rimola J, Forner A, Tremosini S et al (2012) Non-invasive diagnosis of hepatocellular carcinoma 10.1016/j.jhep.2012.01.004)
Baffy G, Brunt EM, Caldwell SH (2012) Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol 56:1384–1391. (PMID: 10.1016/j.jhep.2011.10.027)
Neri E, Bali MA, Ba-Ssalamah A et al (2016) ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents. Eur Radiol 26:921–931. (PMID: 10.1007/s00330-015-3900-3)
Pokharel SS, Macura KJ, Kamel IR, Zaheer A (2013) Current MR imaging lipid detection techniques for diagnosis of lesions in the abdomen and pelvis. Radiographics 33:681–702. (PMID: 10.1148/rg.333125068)
Liu YI, Shin LK, Jeffrey RB, Kamaya A (2013) Quantitatively defining washout in hepatocellular carcinoma. AJR Am J Roentgenol 200:84–89. (PMID: 10.2214/AJR.11.7171)
Kim YN, Song JS, Moon WS, Hwang HP, Kim YK (2018) Intra-individual comparison of hepatocellular carcinoma imaging features on contrast-enhanced computed tomography, gadopentetate dimeglumine-enhanced MRI, and gadoxetic acid-enhanced MRI. Acta Radiol 59:639–648. (PMID: 10.1177/0284185117728534)
Sofue K, Sirlin CB, Allen BC, Nelson RC, Berg CL, Bashir MR (2016) How reader perception of capsule affects interpretation of washout in hypervascular liver nodules in patients at risk for hepatocellular carcinoma. J Magn Reson Imaging 43:1337–1345. (PMID: 10.1002/jmri.25094)
Li XH, Zhu J, Zhang XM et al (2014) Abdominal MRI at 3.0 T: LAVA-Flex compared with conventional fat suppression T1-weighted images. J Magn Reson Imaging 40:58–66. (PMID: 10.1002/jmri.24329)
Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174. (PMID: 10.2307/2529310)
Kleiner DE, Brunt EM, Van Natta M et al (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313–1321. (PMID: 10.1002/hep.20701)
Yeh MM, Brunt EM (2014) Pathological features of fatty liver disease. Gastroenterology 147:754–764. (PMID: 10.1053/j.gastro.2014.07.056)
Marrero JA, Hussain HK, Nghiem HV, Umar R, Fontana RJ, Lok AS (2005) Improving the prediction of hepatocellular carcinoma in cirrhotic patients with an arterially-enhancing liver mass. Liver Transpl 11:281–289. (PMID: 10.1002/lt.20357)
Matsui O (2004) Imaging of multistep human hepatocarcinogenesis by CT during intra-arterial contrast injection. Intervirology 47:271–276. (PMID: 10.1159/000078478)
Park YN, Yang CP, Fernandez GJ, Cubukcu O, Thung SN, Theise ND (1998) Neoangiogenesis and sinusoidal “capillarization” in dysplastic nodules of the liver. Am J Surg Pathol 22:656–662. (PMID: 10.1097/00000478-199806000-00002)
Iannaccone R, Piacentini F, Murakami T et al (2007) Hepatocellular carcinoma in patients with nonalcoholic fatty liver disease: helical CT and MR imaging findings with clinical-pathologic comparison. Radiology 243:422–430. (PMID: 10.1148/radiol.2432051244)
Rofsky NM, Fleishaker H (1995) CT and MRI of diffuse liver disease. Semin Ultrasound CT MR 16:16–33. (PMID: 10.1016/0887-2171(95)90012-8)
Koplay M, Sivri M, Erdogan H, Nayman A (2015) Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease. World J Hepatol 7:769–776. (PMID: 10.4254/wjh.v7.i5.769)
Lewis E, Bernardino ME, Barnes PA, Parvey HR, Soo CS, Chuang VP (1983) The fatty liver: pitfalls of the CT and angiographic evaluation of metastatic disease. J Comput Assist Tomogr 7:235–241. (PMID: 10.1097/00004728-198304000-00005)
Mitchell DG (1992) Focal manifestations of diffuse liver disease at MR imaging. Radiology 185:1–11. (PMID: 10.1148/radiology.185.1.1523289)
Kato M, Saji S, Kanematsu M et al (1997) A case of liver metastasis from colon cancer masquerading as focal sparing in a fatty liver. Jpn J Clin Oncol 27:189–192. (PMID: 10.1093/jjco/27.3.189)
Chung JJ, Kim MJ, Kim JH, Lee JT, Yoo HS (2003) Fat sparing of surrounding liver from metastasis in patients with fatty liver: MR imaging with histopathologic correlation. AJR Am J Roentgenol 180:1347–1350. (PMID: 10.2214/ajr.180.5.1801347)
Baron RL (1994) Understanding and optimizing use of contrast material for CT of the liver. AJR Am J Roentgenol 163:323–331. (PMID: 10.2214/ajr.163.2.8037023)
Ward J (2006) New MR techniques for the detection of liver metastases. Cancer Imaging 6:33–42. (PMID: 10.1102/1470-7330.2006.0007)
Kim SS, Hwang JA, Shin HC et al (2019) LI-RADS v2017 categorisation of HCC using CT: does moderate to severe fatty liver affect accuracy? Eur Radiol 29:186–194. (PMID: 10.1007/s00330-018-5657-y)
Thompson SM, Garg I, Ehman EC et al (2018) Non-alcoholic fatty liver disease-associated hepatocellular carcinoma: effect of hepatic steatosis on major hepatocellular carcinoma features at MRI. Br J Radiol 91:20180345. (PMID: 10.1259/bjr.20180345)
Joo I, Lee JM, Lee DH, Jeon JH, Han JK (2019) Retrospective validation of a new diagnostic criterion for hepatocellular carcinoma on gadoxetic acid-enhanced MRI: can hypointensity on the hepatobiliary phase be used as an alternative to washout with the aid of ancillary features? Eur Radiol 29:1724–1732. (PMID: 10.1007/s00330-018-5727-1)
Kim DH, Choi SH, Kim SY, Kim MJ, Lee SS, Byun JH (2019) Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: value of washout in transitional and hepatobiliary phases. Radiology 291:651–657. (PMID: 10.1148/radiol.2019182587)
Contributed Indexing :
Keywords: Diagnosis; Fatty liver; Hepatocellular carcinoma; Magnetic resonance imaging; Multidetector computed tomography
Substance Nomenclature :
0 (Contrast Media)
K2I13DR72L (Gadolinium DTPA)
Entry Date(s) :
Date Created: 20201107 Date Completed: 20210415 Latest Revision: 20210415
Update Code :
20210416
DOI :
10.1007/s00330-020-07438-9
PMID :
33159576
Czasopismo naukowe
Objectives: To compare the presence of washout and the diagnostic performance of computed tomography (CT) and magnetic resonance imaging (MRI) for hepatocellular carcinoma (HCC) according to the presence of hepatic steatosis.
Methods: This retrospective study included 566 patients with chronic liver disease who had undergone hepatic resection for hepatic tumors (482 HCCs and 84 non-HCCs) between January 2016 and June 2018 and had available multiphasic CT and MR images. Patients were allocated in the fatty liver (n = 141) or non-fatty liver (n = 425) group according to the presence of hepatic steatosis, defined as lipid droplets in at least 5% of hepatocytes on pathological examination. The presence of HCC washout and the diagnostic performance of CT and MRI for HCC were compared between the groups.
Results: HCC washout was less frequently seen in the fatty liver group than in the non-fatty liver group on CT (61.5% vs. 88.9%, p < 0.001), whereas it was similarly present on MRI in both groups (77.0% vs. 74.4%, p = 0.565). For diagnosis of HCC, the sensitivity (53.3% vs. 80.0%, p < 0.001) and accuracy (53.9% vs. 80.9%, p < 0.001) of CT were lower in the fatty liver group than in the non-fatty liver group. However, for MRI, these values were not significantly different between the groups (p > 0.05).
Conclusions: Hepatic steatosis significantly decreased the performance of CT for the diagnosis of HCC, whereas it did not significantly alter the performance of MRI.
Key Points: • Unlike MRI, there is vanishing HCC washout on CT caused by the background hepatic steatosis. • The diagnostic performance of CT for the diagnosis of HCC was significantly altered by hepatic steatosis. • The optimal cutoff HU value of the liver parenchyma for the vanishing washout of HCC was < 50 HU on unenhanced CT images.

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