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Tytuł pozycji:

Enhanced chemodynamic therapy at weak acidic pH based on g-C 3 N 4 -supported hemin/Au nanoplatform and cell apoptosis monitoring during treatment.

Tytuł :
Enhanced chemodynamic therapy at weak acidic pH based on g-C 3 N 4 -supported hemin/Au nanoplatform and cell apoptosis monitoring during treatment.
Autorzy :
Wang YN; Research Center for Analytical Sciences, Northeastern University, Shenyang, 110819, China.
Song D; Research Center for Analytical Sciences, Northeastern University, Shenyang, 110819, China.
Zhang WS; Research Center for Analytical Sciences, Northeastern University, Shenyang, 110819, China.
Xu ZR; Research Center for Analytical Sciences, Northeastern University, Shenyang, 110819, China. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Jan; Vol. 197, pp. 111437. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Amsterdam ; New York : Elsevier, c1993-
Contributed Indexing :
Keywords: Biomimetic nanocatalyst; Cell apoptosis monitoring; Chemodynamic therapy; Fenton catalytic activity; Hemin
Entry Date(s) :
Date Created: 20201109 Latest Revision: 20201215
Update Code :
20201231
DOI :
10.1016/j.colsurfb.2020.111437
PMID :
33166930
Czasopismo naukowe
Chemodynamic therapy (CDT), inducing tumor cell apoptosis through Fenton reaction to produce hydroxyl radical (·OH), is an emerging cancer treatment technology. Highly efficient Fenton catalytic reactions usually take place at a low pH environment. Utilizing graphitic carbon nitride supported hemin and Au nanoparticles (g-C 3 N 4 /hemin/Au) as a novel biomimetic nanocatalyst, we achieve an enhanced CDT for inducing tumor cell apoptosis in the presence of excess H 2 O 2 , and reveal the molecular events during the CDT-induced apoptosis. The prepared g-C 3 N 4 /hemin/Au nanohybrids exhibit excellent Fenton catalytic activity for the generation of highly toxic ·OH at weak acidic and neutral condition, which breaks through the limitation of traditional acidity-dependent response. The Fenton catalytic mechanism was also studied. The Fenton efficiency is primarily enhanced by the high affinity between nanohybrids and H 2 O 2 , and the transformation of Fe(III) to Fe(IV)=O without the formation of iron hydrate precipitation. Moreover, the intracellular molecular events during the CDT process were monitored. Phenylalanine metabolism was perturbed with protein degradation and DNA structures were damaged, which eventually lead to cell apoptosis. This study provides a significant guidance for the further development of more effective CDT platforms.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

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