Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility.

Tytuł:: Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility.
Autorzy:: Lu Y; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666; y_.
Sandoval A; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
Voss S; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
Lai Z; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Kneitz S; Physiological Chemistry, Biozentrum, University of Würzburg, 97070 Würzburg, Germany.
Boswell W; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
Boswell M; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
Savage M; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
Walter C; Department of Cellular & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Warren W; Bond Life Science Center, University of Missouri, Columbia, MO 65211.
Schartl M; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.; Developmental Biochemistry, Biozentrum, University of Würzburg, 97070 Würzburg, Germany.
Walter R; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666; y_.
Źródło:: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 24; Vol. 117 (47), pp. 29786-29794. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Original Publication: Washington, DC : National Academy of Sciences
MeSH Terms:: Hybridization, Genetic*
Models, Genetic*
Cyprinodontiformes/*genetics
Fish Diseases/*genetics
Melanoma/*veterinary
Animals ; Animals, Genetically Modified ; Carcinogenesis/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Female ; Fish Proteins/genetics ; Genetic Loci ; Genetic Speciation ; Male ; Melanoma/genetics ; Models, Animal ; Species Specificity ; rab3 GTP-Binding Proteins/genetics
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Grant Information:: R15 CA223964 United States CA NCI NIH HHS; R24 OD011120 United States OD NIH HHS
Contributed Indexing:: Keywords: Bateson–Dobzhansky–Muller model; Xiphophorus; evolution; genetics; hybrid incompatibility
Substance Nomenclature:: 0 (Cyclin-Dependent Kinase Inhibitor p16)
0 (Fish Proteins)
EC 3.6.5.2 (rab3 GTP-Binding Proteins)
Entry Date(s):: Date Created: 20201110 Date Completed: 20210119 Latest Revision: 20210506
Update Code:: 20240105
PubMed Central ID:: PMC7703647
DOI:: 10.1073/pnas.2010133117
PMID:: 33168740
: Czasopismo naukowe

Mixing genomes of different species by hybridization can disrupt species-specific genetic interactions that were adapted and fixed within each species population. Such disruption can predispose the hybrids to abnormalities and disease that decrease the overall fitness of the hybrids and is therefore named as hybrid incompatibility. Interspecies hybridization between southern platyfish and green swordtails leads to lethal melanocyte tumorigenesis. This occurs in hybrids with tumor incidence following progeny ratio that is consistent with two-locus interaction, suggesting melanoma development is a result of negative epistasis. Such observations make Xiphophorus one of the only two vertebrate hybrid incompatibility examples in which interacting genes have been identified. One of the two interacting loci has been characterized as a mutant epidermal growth factor receptor. However, the other locus has not been identified despite over five decades of active research. Here we report the localization of the melanoma regulatory locus to a single gene, rab3d , which shows all expected features of the long-sought oncogene interacting locus. Our findings provide insights into the role of egfr regulation in regard to cancer etiology. Finally, they provide a molecular explainable example of hybrid incompatibility.
Competing Interests: The authors declare no competing interest.
(Copyright © 2020 the Author(s). Published by PNAS.)

Comment in: Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):. (PMID: 33380463)

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