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Tytuł:
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Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review).
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Autorzy:
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Ma WJ; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Yin YC; Department of Pharmacy, Shaoyang Central Hospital, Shaoyang, Hunan 422000, P.R. China.
Zhang BK; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Li YJ; Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, P.R. China.
Li WQ; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
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Źródło:
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Molecular medicine reports [Mol Med Rep] 2021 Jan; Vol. 23 (1). Date of Electronic Publication: 2020 Nov 12.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Athens, Greece : D. A. Spandidos
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MeSH Terms:
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Calcitonin Gene-Related Peptide/*metabolism
Cardiovascular Diseases/*metabolism
Gastrointestinal Diseases/*metabolism
Indole Alkaloids/*pharmacology
Nitroglycerin/*pharmacology
Quinazolines/*pharmacology
Cardiovascular Diseases/drug therapy ; Gastrointestinal Diseases/drug therapy ; Gene Expression Regulation/drug effects ; Humans ; Indole Alkaloids/therapeutic use ; Molecular Targeted Therapy ; Nitroglycerin/therapeutic use ; Quinazolines/therapeutic use ; Up-Regulation
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Contributed Indexing:
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Keywords: calcitonin gene‑related peptide; nitroglycerine; rutaecarpine; sartans; capsaicin
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Substance Nomenclature:
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0 (Indole Alkaloids)
0 (Quinazolines)
8XZV289PRY (rutecarpine)
G59M7S0WS3 (Nitroglycerin)
JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
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Entry Date(s):
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Date Created: 20201112 Date Completed: 20210519 Latest Revision: 20210630
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Update Code:
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20240105
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DOI:
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10.3892/mmr.2020.11665
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PMID:
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33179114
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Calcitonin gene‑related peptide (CGRP) is the predominant neurotransmitter located in sensory nerves. This peptide is extensively distributed in central and peripheral tissues. CGRP causes relaxation of cardiovascular smooth muscle cells and confers protection against ischaemic myocardium and cardiac remodeling. The pharmacological effects of nitroglycerine and rutaecarpine have been demonstrated to be associated with an increase in the synthesis and release of CGRP. In the gastrointestinal tissues, CGRP participates in the regulation of gastrointestinal function, and exerts protective effects on gastric mucosa. Rutaecarpine, capsaicin and its derivatives, such as evodiamine, decrease gastric mucosal damage induced by several factors, including increased synthesis and release of CGRP. Taken together, this review focuses on the pharmacological effects of several CGRP related canonical drugs and suggests that synthesis and secretion of CGRP exhibit significant therapeutic effects in the occurrence and development of cardiovascular and gastrointestinal diseases.
