-
Tytuł:
-
Untargeted metabolomics for Achilles heel of engineered nanomaterials' risk assessment.
-
Autorzy:
-
Ahmad F; School of Material Science and Engineering, Nanjing University, Jiangsu, China. Electronic address: .
Abubshait SA; Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, 31441, Dammam, Saudi Arabia; Basic and Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, 31441, Dammam, Saudi Arabia.
Abubshait HA; Basic Sciences Department, Deanship of Preparatory Year and Supporting Studies, Imam Adulrahman Bin Faisal University, Dammam, Saudi Arabia.
-
Źródło:
-
Chemosphere [Chemosphere] 2021 Jan; Vol. 262, pp. 128058. Date of Electronic Publication: 2020 Aug 23.
-
Typ publikacji:
-
Journal Article; Review
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford, New York, : Pergamon Press.
-
MeSH Terms:
-
Nanostructures*/chemistry
Nanostructures*/toxicity
Metabolic Networks and Pathways/*drug effects
Metabolomics/*methods
Humans ; Nanotechnology ; Risk Assessment ; Signal Transduction
-
Contributed Indexing:
-
Keywords: Metabolomics; Nanomaterials; Nanotoxicity; Risk assessment
-
Entry Date(s):
-
Date Created: 20201113 Date Completed: 20201126 Latest Revision: 20201126
-
Update Code:
-
20240105
-
DOI:
-
10.1016/j.chemosphere.2020.128058
-
PMID:
-
33182140
-
Owing to the superlative properties, engineered nanomaterials (ENM) are being used in food, cosmetics, medicine, and electronics. Therefore, exogenous ENM can be housed into humans through a multitude of exposure routes, leading to compromise of the biomolecules' functionalities through structural deformations, and even at the metabolic level. Consequently, it is of great importance to understand the perturbations introduced at the metabolic level for the timely risk assessment (RA) of ENM. Current technological advancements in metabolomics empower us to visualize the metabolic dysregulations in biological cells, tissues, and living objects, instigated by the ENM. Given the fact, we propose multitiered untargeted metabolomics for the risk assessment of ENM. We propose largely validated experimental design principles that enable the well-organized and authentic identification of metabolic dysregulation connected with a newly engineered nanomaterial. Our scheme could participate in the enhanced transparency of the RA course of rapidly emerging ENM.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
