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Tytuł:
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Comparative Assessment of Revascularization Versus Drug Management in Coronary Artery Disease (CAD) Associated with Left Ventricular Dysfunction (EF < 40%) - A 12 Month Study with FDG PET and SPECT MPI Analyses.
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Autorzy:
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Kumar V; Director Cath Labs. Max Superspeciality Hospital, New Delhi.
Bashir H; Associate Professor, Goverment Medical College Srinagar, Jammu and Kashmir.
Yadav M; Consultant, Max Superspeciality Hospital, New Delhi.
Kumar V; Consultant, Max Superspeciality Hospital, New Delhi.
Bhargav M; Consultant, Max Superspeciality Hospital, New Delhi.
Jatin S; Consultant, Max Superspeciality Hospital, New Delhi.
Goel A; Consultant, Max Superspeciality Hospital, New Delhi.
Dhir S; Consultant, Max Superspeciality Hospital, New Delhi.
Roy CP; Consultant, Max Superspeciality Hospital, New Delhi.
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Źródło:
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The Journal of the Association of Physicians of India [J Assoc Physicians India] 2020 Nov; Vol. 68 (11), pp. 28-33.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Bombay : Association of Physicians of India
Original Publication: Bombay [1953?]-
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MeSH Terms:
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Coronary Artery Disease*/complications
Coronary Artery Disease*/diagnostic imaging
Ventricular Dysfunction, Left*/diagnostic imaging
Fluorodeoxyglucose F18 ; Humans ; Myocardial Revascularization ; Positron-Emission Tomography ; Tomography, Emission-Computed, Single-Photon
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Substance Nomenclature:
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0Z5B2CJX4D (Fluorodeoxyglucose F18)
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Entry Date(s):
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Date Created: 20201113 Date Completed: 20201117 Latest Revision: 20220418
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Update Code:
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20240105
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PMID:
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33187033
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Aim of the Study: Left Ventricular (LV) function and myocardial viability is the key predictor of prognosis after myocardial infarction. Management of ischemic cardiomyopathy (revascularization and or drugs alone) is the objective of this study.
Methodology: 72 patients were assigned to revascularization and medical management group based on the inclusion criteria Follow up was done upto 12 months with advanced imaging techniques (FDG PET and SPECT MPI analyses).
Results: Subjects with significant viable myocardium, revascularization resulted in significant improvement in heart failure symptoms. The mean NYHA functional class improved from 2.9 ± 0.3 to 2.3 ± 0.5(mean ± SD) after 6 months of revascularization (p < 0.01). This improvement in functional class was maintained after 12 months of revascularization (2.0 ± 0.4 (mean ± SD). Subjects on medical management with a baseline NYHA functional class 2.7 ± 0.5, at 6 months of follow, there was no significant change in functional class (2.8 ± 0.3) (p<0.24). However at 12 months follow up functional class had dropped to 3.0 + 0.3, which was significant as compared to baseline (p <0.03).
Conclusion: coronary revascularization has a protective effect on patients with ischemic coronary who have viable myocardium and reversible myocardial ischemia as assessed by 18F-FDG PET and SPECT MPI Imaging.
(© Journal of the Association of Physicians of India 2011.)
