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Tytuł pozycji:

BrainWiki-A Wiki-Style, User Driven, Comparative Brain Anatomy Tool.

Tytuł :
BrainWiki-A Wiki-Style, User Driven, Comparative Brain Anatomy Tool.
Autorzy :
Forsell L; Department of Pathology and Cell Biology, Taub Institute, Columbia University Irving Medical Center, New York, NY, United States.; Karolinska Institutet, Stockholm, Sweden.
Vos EN; Karolinska Institutet, Stockholm, Sweden.
Jayaraman K; Department of Pathology and Cell Biology, Taub Institute, Columbia University Irving Medical Center, New York, NY, United States.
Edman A; Karolinska Institutet, Stockholm, Sweden.
Hussaini SA; Department of Pathology and Cell Biology, Taub Institute, Columbia University Irving Medical Center, New York, NY, United States.
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Źródło :
Frontiers in neuroanatomy [Front Neuroanat] 2020 Oct 19; Vol. 14, pp. 548172. Date of Electronic Publication: 2020 Oct 19 (Print Publication: 2020).
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007-
References :
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Contributed Indexing :
Keywords: brain anatomy; brain atlas; brain circuits; brain functions; brain pathology; comparative anatomy; human brain; mouse brain
Entry Date(s) :
Date Created: 20201116 Latest Revision: 20201117
Update Code :
20210210
PubMed Central ID :
PMC7604473
DOI :
10.3389/fnana.2020.548172
PMID :
33192339
Czasopismo naukowe
The mouse is the most important animal model within neuroscientific research, a position strengthened by the wide-spread use of transgenic mouse models. Discoveries in animals are followed by corroboration in humans, and the interchange between these fields of research is essential to our understanding of the human brain. With the advent of advanced technologies such as single-cell transcriptomics, epigenetic profiling and diffusion MRI, many prominent research institutes and collaborations have emerged, aiming to construct complete human or mouse brain atlases with data on gene expression, connectivity and cell types. These initiatives are indispensable resources, but frequently require extensive, time-consuming development, and rely on updates by the provider. They often come in the shape of applications which require practice or prior technical know-how. Importantly, none of them place the human and the mouse brain next to each other to allow for immediate comparison. We present BrainWiki, a user-friendly, web-based atlas that links the human and the mouse brain together, side-by-side. The platform gives the user a simple overview of brain anatomy along with published articles relating to each brain region that allows the user to delve deeper into the current state of research concerning circuitry, brain functions and pathology. The website relies on interactivity and supports user contributions resulting in a dynamic website that evolves at the pace of neuroscience. It is designed to allow for constant updates and new features in the future which will contain data such as gene expression and neuronal cell types.
(Copyright © 2020 Forsell, Vos, Jayaraman, Edman and Hussaini.)

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