Differentiation of human induced pluripotent stem cells into erythroid cells.

Tytuł:: Differentiation of human induced pluripotent stem cells into erythroid cells.
Autorzy:: Ebrahimi M; Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Forouzesh M; Legal Medicine Organization of Iran, Legal Medicine Research Center, Legal Medicine organization, Tehran, Iran.
Raoufi S; Faculty of Medical Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Ramazii M; Kerman University of Medical Sciences, University of Kerman, Kerman, Iran.
Ghaedrahmati F; Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Farzaneh M; Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. .
Źródło:: Stem cell research & therapy [Stem Cell Res Ther] 2020 Nov 16; Vol. 11 (1), pp. 483. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: London : BioMed Central
MeSH Terms:: Human Embryonic Stem Cells*
Induced Pluripotent Stem Cells*
Cell Differentiation ; Embryonic Stem Cells ; Erythroid Cells ; Humans ; Kruppel-Like Factor 4
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Contributed Indexing:: Keywords: Blood disorders; Differentiation; Erythrocytes; Induced pluripotent stem cells; Large-scale; Reprogramming
Entry Date(s):: Date Created: 20201117 Date Completed: 20210618 Latest Revision: 20211204
Update Code:: 20240105
PubMed Central ID:: PMC7667818
DOI:: 10.1186/s13287-020-01998-9
PMID:: 33198819
: Czasopismo naukowe

Pełny tekst

During the last years, several strategies have been made to obtain mature erythrocytes or red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB-derived hematopoietic stem cells (HSC) are a limited source and in vitro large-scale expansion of RBC from HSC remains problematic. One promising alternative can be human pluripotent stem cells (PSCs) that provide an unlimited source of cells. Human PSCs, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are self-renewing progenitors that can be differentiated to lineages of ectoderm, mesoderm, and endoderm. Several previous studies have revealed that human ESCs can differentiate into functional oxygen-carrying erythrocytes; however, the ex vivo expansion of human ESC-derived RBC is subjected to ethical concerns. Human iPSCs can be a suitable therapeutic choice for the in vitro/ex vivo manufacture of RBCs. Reprogramming of human somatic cells through the ectopic expression of the transcription factors (OCT4, SOX2, KLF4, c-MYC, LIN28, and NANOG) has provided a new avenue for disease modeling and regenerative medicine. Various techniques have been developed to generate enucleated RBCs from human iPSCs. The in vitro production of human iPSC-derived RBCs can be an alternative treatment option for patients with blood disorders. In this review, we focused on the generation of human iPSC-derived erythrocytes to present an overview of the current status and applications of this field.

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