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Tytuł:
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Monitoring Insecticide Resistance and Target Site Mutations of L1014 Kdr And G119 Ace Alleles in Five Mosquito Populations in Korea.
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Autorzy:
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Park SH; Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine, Incheon 22212, Korea.
Jun H; Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine, Incheon 22212, Korea.
Ahn SK; Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine, Incheon 22212, Korea.
Lee J; Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine, Incheon 22212, Korea.
Yu SL; Inha Research Institute for Medical Sciences, Inha University School of Medicine, Incheon 22212, Korea.
Lee SK; Department of Pharmacology, Inha University School of Medicine, Incheon 22212, Korea.
Kang JM; Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
Kim H; Division of Vectors and Parasitic Diseases, Korea Centers for Disease Control and Prevention, Osong 28159, Korea.
Lee HI; Division of Vectors and Parasitic Diseases, Korea Centers for Disease Control and Prevention, Osong 28159, Korea.
Hong SJ; Department of Medical Environmental Biology, Chung-Ang University College of Medicine, Seoul 06974, Korea.
Na BK; Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
Bahk YY; Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Korea.
Kim TS; Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine, Incheon 22212, Korea.
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Źródło:
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The Korean journal of parasitology [Korean J Parasitol] 2020 Oct; Vol. 58 (5), pp. 543-550. Date of Electronic Publication: 2020 Oct 22.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Seoul, Korea : Korean Society for Parasitology, c1993-2022.
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MeSH Terms:
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Alleles*
Mosquito Control*
Insect Proteins/*genetics
Insecticide Resistance/*genetics
Insecticides/*pharmacology
Mosquito Vectors/*drug effects
Mosquito Vectors/*genetics
Mutation/*drug effects
Animals ; Environmental Monitoring ; Humans ; Mosquito Vectors/classification ; Republic of Korea ; Vector Borne Diseases/prevention & control ; Vector Borne Diseases/transmission
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References:
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Grant Information:
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Inha University; 2017NER44030 Republic of Korea Korea Centers for Disease Control and Prevention
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Contributed Indexing:
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Keywords: ace; insecticide resistance; kdr; mutation
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Substance Nomenclature:
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0 (Insect Proteins)
0 (Insecticides)
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Entry Date(s):
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Date Created: 20201117 Date Completed: 20201130 Latest Revision: 20201130
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Update Code:
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20240105
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PubMed Central ID:
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PMC7672240
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DOI:
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10.3347/kjp.2020.58.5.543
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PMID:
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33202506
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Mosquitoes are globally distributed and important vectors for the transmission of many human diseases. Mosquito control is a difficult task and the cost of preventing mosquito-borne diseases is much lower than that for curing the associated diseases. Thus, chemical control remains the most effective tool for mosquito. Due to the long-term intensive use of insecticides to control mosquito vectors, resistance to most chemical insecticides has been reported. This study aimed to investigate the relationship between insecticide resistance and target site mutation of L1014 kdr and G119 ace alleles in 5 species/species group of mosquitoes (Aedes vexans, Ae. albopictus, Anopheles spp., Culex pipiens complex, and Cx. tritaeniorhynchus) obtained from 6 collection sites. For Anopheles spp., the proportion of mosquitoes with mutated alleles in L1014 was 88.4%, homozygous resistant genotypes were observed in 46.7%, and heterozygous resistant genotypes were observed in 41.8%. For the Cx. pipiens complex and Cx. tritaeniorhynchus species, homozygous resistant genotypes were found in 25.9% and 9.8%, respectively. However, target site mutation of L1014 in the Ae. vexans nipponii and Ae. albopictus species was not observed. Anopheles spp., Cx. pipiens complex, and Cx. tritaeniorhynchus mosquitoes were resistant to deltamethrin and chlorpyriphos, whereas Ae. vexans nipponii and Ae. albopictus were clearly susceptible. We also found a correlation between the resistance phenotype and the presence of the L1014 kdr and G119 ace mutations only in the Anopheles spp. population. In this study, we suggest that insecticide resistance poses a growing threat and resistance management must be integrated into all mosquito control programs.
