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Tytuł pozycji:

Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration.

Tytuł:
Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration.
Autorzy:
Morozov YM; Department of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, Yale University, New Haven, CT 6510, USA.
Mackie K; Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405-2204, USA.; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405-2204, USA.
Rakic P; Department of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, Yale University, New Haven, CT 6510, USA.
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 17; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 17.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:
Cell Movement*
Cell Proliferation*
Neurogenesis*
Neural Stem Cells/*metabolism
Neurons/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Animals ; Macaca mulatta ; Mice ; Mice, Knockout ; Neural Stem Cells/cytology ; Neurons/cytology ; Receptor, Cannabinoid, CB1/genetics
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Grant Information:
R37 DA023999 United States DA NIDA NIH HHS; MH113257 United States MH NIMH NIH HHS; DA023999 United States NH NIH HHS
Contributed Indexing:
Keywords: CB1 receptor; IHC data interpretation; electron microscopic 3D reconstruction; endocannabinoids; neurogenesis; neuron migration
Substance Nomenclature:
0 (Receptor, Cannabinoid, CB1)
Entry Date(s):
Date Created: 20201120 Date Completed: 20210303 Latest Revision: 20210303
Update Code:
20240105
PubMed Central ID:
PMC7696736
DOI:
10.3390/ijms21228657
PMID:
33212822
Czasopismo naukowe
Cannabinoid type 1 receptor (CB 1 R) is expressed and participates in several aspects of cerebral cortex embryonic development as demonstrated with whole-transcriptome mRNA sequencing and other contemporary methods. However, the cellular location of CB 1 R, which helps to specify molecular mechanisms, remains to be documented. Using three-dimensional (3D) electron microscopic reconstruction, we examined CB 1 R immunolabeling in proliferating neural stem cells (NSCs) and migrating neurons in the embryonic mouse ( Mus musculus ) and rhesus macaque ( Macaca mulatta ) cerebral cortex. We found that the mitotic and postmitotic ventricular and subventricular zone (VZ and SVZ) cells are immunonegative in both species while radially migrating neurons in the intermediate zone (IZ) and cortical plate (CP) contain CB 1 R-positive intracellular vesicles. CB 1 R immunolabeling was more numerous and more extensive in monkeys compared to mice. In CB 1 R-knock out mice, projection neurons in the IZ show migration abnormalities such as an increased number of lateral processes. Thus, in radially migrating neurons CB 1 R provides a molecular substrate for the regulation of cell movement. Undetectable level of CB 1 R in VZ/SVZ cells indicates that previously suggested direct CB 1 R-transmitted regulation of cellular proliferation and fate determination demands rigorous re-examination. More abundant CB 1 R expression in monkey compared to mouse suggests that therapeutic or recreational cannabis use may be more distressing for immature primate neurons than inferred from experiments with rodents.
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