Free water: A marker of age-related modifications of the cingulum white matter and its association with cognitive decline.

Tytuł:: Free water: A marker of age-related modifications of the cingulum white matter and its association with cognitive decline.
Autorzy:: Edde M; EPHE, PSL, Bordeaux, France.; CNRS, INCIA, UMR 5287, Bordeaux, France.
Theaud G; Sherbrooke Connectivity Imaging Lab, Université de Sherbrooke, Sherbrooke, QC, Canada.
Rheault F; Sherbrooke Connectivity Imaging Lab, Université de Sherbrooke, Sherbrooke, QC, Canada.
Dilharreguy B; CNRS, INCIA, UMR 5287, Bordeaux, France.
Helmer C; Université de Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Dartigues JF; Université de Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.; CHU de Bordeaux, Bordeaux, France.
Amieva H; Université de Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Allard M; EPHE, PSL, Bordeaux, France.; CNRS, INCIA, UMR 5287, Bordeaux, France.; CHU de Bordeaux, Bordeaux, France.
Descoteaux M; Sherbrooke Connectivity Imaging Lab, Université de Sherbrooke, Sherbrooke, QC, Canada.
Catheline G; EPHE, PSL, Bordeaux, France.; CNRS, INCIA, UMR 5287, Bordeaux, France.; Université de Bordeaux, INCIA, UMR 5287, Bordeaux, France.
Źródło:: PloS one [PLoS One] 2020 Nov 20; Vol. 15 (11), pp. e0242696. Date of Electronic Publication: 2020 Nov 20 (Print Publication: 2020).
Typ publikacji:: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Cognition*
Cognitive Dysfunction*/diagnostic imaging
Cognitive Dysfunction*/metabolism
Diffusion Tensor Imaging*
White Matter*/diagnostic imaging
White Matter*/metabolism
Aging/*metabolism
Water/*metabolism
Aged, 80 and over ; Female ; Humans ; Male
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Substance Nomenclature:: 059QF0KO0R (Water)
Entry Date(s):: Date Created: 20201120 Date Completed: 20210104 Latest Revision: 20240330
Update Code:: 20240330
PubMed Central ID:: PMC7678997
DOI:: 10.1371/journal.pone.0242696
PMID:: 33216815
: Czasopismo naukowe

Pełny tekst

Diffusion MRI is extensively used to investigate changes in white matter microstructure. However, diffusion measures within white matter tissue can be affected by partial volume effects due to cerebrospinal fluid and white matter hyperintensities, especially in the aging brain. In previous aging studies, the cingulum bundle that plays a central role in the architecture of the brain networks supporting cognitive functions has been associated with cognitive deficits. However, most of these studies did not consider the partial volume effects on diffusion measures. The aim of this study was to evaluate the effect of free water elimination on diffusion measures of the cingulum in a group of 68 healthy elderly individuals. We first determined the effect of free water elimination on conventional DTI measures and then examined the effect of free water elimination on verbal fluency performance over 12 years. The cingulum bundle was reconstructed with a tractography pipeline including a white matter hyperintensities mask to limit the negative impact of hyperintensities on fiber tracking algorithms. We observed that free water elimination increased the ability of conventional DTI measures to detect associations between tissue diffusion measures of the cingulum and changes in verbal fluency in older individuals. Moreover, free water content and mean diffusivity measured along the cingulum were independently associated with changes in verbal fluency. This suggests that both tissue modifications and an increase in interstitial isotropic water would contribute to cognitive decline. These observations reinforce the importance of using free water elimination when studying brain aging and indicate that free water itself could be a relevant marker for age-related cingulum white matter modifications and cognitive decline.
Competing Interests: The authors have read the journal’s policy and have the following competing interests: This study was supported in part by Sanofi-Aventis, who funded the collection of initial data for the 3C cohort (from 1999 to 2005). There are no employment relationships, consultancies or other awards to declare. There are no patents, products in development, or marketed products to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

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