Perinatal outcome and prognostic factors of fetal megacystis diagnosed at 11-14 week's gestation.

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Tytuł:: Perinatal outcome and prognostic factors of fetal megacystis diagnosed at 11-14 week's gestation.
Autorzy:: Kao C; Department of Obstetrics and Gynecology, University of Calgary, Alberta, Canada.
Lauzon J; Department of Medical Genetics, University of Calgary, Alberta, Canada.
Brundler MA; Department of Pathology & Laboratory Medicine and Pediatrics, University of Calgary, Alberta, Canada.
Tang S; Department of Obstetrics and Gynecology, University of Calgary, Alberta, Canada.
Somerset D; Department of Obstetrics and Gynecology, University of Calgary, Alberta, Canada.
Źródło:: Prenatal diagnosis [Prenat Diagn] 2021 Feb; Vol. 41 (3), pp. 308-315. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Chichester, [Sussex]; New York : Wiley, c1981-
MeSH Terms:: Prognosis*
Duodenum/*abnormalities
Fetal Diseases/*mortality
Urinary Bladder/*abnormalities
Adult ; Female ; Fetal Diseases/epidemiology ; Gestational Age ; Humans ; Pregnancy ; Pregnancy Outcome/epidemiology ; Prenatal Diagnosis ; Retrospective Studies ; Ultrasonography/methods
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Liao AW, Sebire NJ, Geerts L, Cicero S, Nicolaides KH. Megacystis at 10-14 weeks of gestation: chromosomal defects and outcome according to bladder length. Ultrasound Obstet Gynecol. 2003;21(4):338-341.
Chen L, Guan J, Gu H, Zhang M. Outcomes in fetuses diagnosed with megacystis: systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2019;233:120-126.
Fontanella F, Maggio L, Verheij JBGM, et al. Fetal megacystis: a lot more than LUTO. Ultrasound Obstet Gynecol. 2019;53(6):779-787.
Bornes M, Spaggiari E, Schmitz T, et al. Outcome and etiologies of fetal megacystis according to the gestational age at diagnosis. Prenat Diagn. 2013;33(12):1162-1166.
Favre R, Kohler M, Gasser B, Muller F, Nisand I. Early fetal megacystis between 11 and 15 weeks of gestation. Ultrasound Obstet Gynecol. 1999;14(6):402-406.
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Boissier K, Varlet MN, Chauleur C, et al. Diagnostic anténatal de mégavessie au premier trimestre de la grossesse. Étude rétrospective sur six années. Gynecol Obstet Fertil. 2009;37(2):115-124.
Fievet L, Faure A, Coze S, et al. Fetal megacystis: etiologies, management, and outcome according to the trimester. Urology. 2014;84(1):185-190.
Fontanella F, Duin L, Adama van Scheltema PN, et al. Antenatal workup of early Megacystis and selection of candidates for Fetal therapy. Fetal Diagn Ther. 2019;45(3):155-161.
Fontanella F, Duin L, Adama van Scheltema PN, et al. Fetal megacystis: prediction of spontaneous resolution and outcome. Ultrasound Obstet Gynecol. 2017;50(4):458-463.
Pellegrino M, Visconti D, Catania VD, et al. Prenatal detection of megacystis: not always an adverse prognostic factor. Experience in 25 consecutive cases in a tertiary referral center, with complete neonatal outcome and follow-up. J Pediatr Urol. 2017;13(5):486.e481-486.e410.
SCR Disease Name:: Megaduodenum
Entry Date(s):: Date Created: 20201121 Date Completed: 20211210 Latest Revision: 20211214
Update Code:: 20240105
DOI:: 10.1002/pd.5868
PMID:: 33219696
: Czasopismo naukowe

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Objectives: To evaluate aneuploidy rate, prognostic factors, and perinatal outcomes following a diagnosis of fetal megacystis at 11-14 week's gestation.
Methods: A retrospective study of first trimester fetal megacystis from 2010 to 2020 was performed, including ultrasound finding, perinatal outcomes, pathology reports, genetic tests, and neonatal investigations.
Results: A total of 98 cases of first trimester fetal megacystis was identified with an overall aneuploidy rate of 12%. There were 54% live births and 46% fetal losses including spontaneous fetal demise and elective termination. Among the 45 fetal losses, 64% had additional structural abnormalities at index ultrasound and final diagnoses were achievable in 64% cases. Among the 53 livebirths, additional ultrasound abnormalities were detected in only 1 fetus and spontaneous resolution of megacystis was detected in 96% of cases. The two cases where fetal megacystis persisted had major postnatal diagnoses: cloacal malformation and megacystis-microcolon-intestinal hypoperistalsis syndrome, respectively. Our data showed LBD ≥ 12 mm was the best individual predictor of adverse perinatal outcome and all 11 cases of lower urinary tract obstruction (LUTO) were diagnosed in fetuses with LBD ≥ 12 mm.
Conclusions: First trimester ultrasound provides important prognostic factors and isolated megacystis <12 mm is associated with a positive outcome.
(© 2020 John Wiley & Sons, Ltd.)

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