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Tytuł:
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Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine.
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Autorzy:
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Sharma HS; International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address: .
Sahib S; Department of Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, United States.
Tian ZR; Department of Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, United States.
Muresanu DF; Department of Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania; 'RoNeuro' Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.
Nozari A; Anesthesiology & Intensive Care, Massachusetts General Hospital, Boston, MA, United States.
Castellani RJ; Department of Pathology, University of Maryland, Baltimore, MD, United States.
Lafuente JV; LaNCE, Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bilbao, Spain.
Wiklund L; International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Sharma A; International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
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Źródło:
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Progress in brain research [Prog Brain Res] 2020; Vol. 258, pp. 233-283. Date of Electronic Publication: 2020 Oct 24.
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Typ publikacji:
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Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier
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MeSH Terms:
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Brain Edema*
Brain Injuries*
Brain Injuries, Traumatic*/drug therapy
Humans ; Nanomedicine ; Protein Kinase Inhibitors
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Grant Information:
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R01 AG028679 United States AG NIA NIH HHS
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Contributed Indexing:
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Keywords: Blood-brain barrier; Brain edema; Brain pathology; Methylene blue; Nanowired delivery; Oxidative stress; Protein kinase inhibitors; Traumatic brain injury
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Substance Nomenclature:
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0 (Protein Kinase Inhibitors)
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Entry Date(s):
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Date Created: 20201123 Date Completed: 20211124 Latest Revision: 20211124
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Update Code:
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20240105
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DOI:
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10.1016/bs.pbr.2020.09.009
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PMID:
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33223036
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Traumatic brain injury (TBI) causes physical injury to the cell membranes of neurons, glial and axons causing the release of several neurochemicals including glutamate and cytokines altering cell-signaling pathways. Upregulation of mitogen associated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) occurs that is largely responsible for cell death. The pharmacological blockade of these pathways results in cell survival. In this review role of several protein kinase inhibitors on TBI induced oxidative stress, blood-brain barrier breakdown, brain edema formation, and resulting brain pathology is discussed in the light of current literature.
(© 2020 Elsevier B.V. All rights reserved.)
