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Tytuł pozycji:

Titanium oxide nano-radiosensitizers for hydrogen peroxide delivery into cancer cells.

Tytuł :
Titanium oxide nano-radiosensitizers for hydrogen peroxide delivery into cancer cells.
Autorzy :
Morita K; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Rokkodaicho 1-1, Nada-ku, Kobe 657-8501, Japan; Research Facility Center for Science and Technology, Kobe University, Rokkodaicho 1-1, Nada-ku, Kobe 657-8501, Japan.
Nishimura Y; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Rokkodaicho 1-1, Nada-ku, Kobe 657-8501, Japan.
Nakamura S; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Rokkodaicho 1-1, Nada-ku, Kobe 657-8501, Japan.
Arai Y; Graduate School of Science, Chiba University, 1-33, Yayoi, Inage, Chiba, 263-8522, Japan.
Numako C; Graduate School of Science, Chiba University, 1-33, Yayoi, Inage, Chiba, 263-8522, Japan.
Sato K; Division of Environmental Engineering Science, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma, 376-8515, Japan.
Nakayama M; Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kusunokicho 7-5-2, Chuou-ku, Kobe 650-0017, Japan.
Akasaka H; Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kusunokicho 7-5-2, Chuou-ku, Kobe 650-0017, Japan.
Sasaki R; Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kusunokicho 7-5-2, Chuou-ku, Kobe 650-0017, Japan.
Ogino C; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Rokkodaicho 1-1, Nada-ku, Kobe 657-8501, Japan. Electronic address: .
Kondo A; Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Rokkodaicho 1-1, Nada-ku, Kobe 657-8501, Japan; Organization of Advanced Science and Technology, Kobe University, Rokkodaicho 1-1, Nada-ku, Kobe 657-8501, Japan.
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2020 Nov 07, pp. 111451. Date of Electronic Publication: 2020 Nov 07.
Publication Model :
Ahead of Print
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Amsterdam ; New York : Elsevier, c1993-
Contributed Indexing :
Keywords: Drug delivery system; Hydrogen peroxide; Radiosensitization; Radiotherapy; Titanium oxide nanoparticle
Entry Date(s) :
Date Created: 20201123 Latest Revision: 20201123
Update Code :
20201218
DOI :
10.1016/j.colsurfb.2020.111451
PMID :
33223346
Czasopismo naukowe
Polyacrylic acid-modified titanium peroxide nanoparticles (PAA-TiO x NPs) are promising radiosensitizers that enhance the therapeutic effect of X-ray irradiation after local injection into tumors. However, the mechanism for this reaction has remained unclear with the exception of the involvement of hydrogen peroxide (H 2 O 2 ), which is released by PAA-TiO x NPs to a liquid phase during dispersion. In the present study, a clonogenic assay was used to compare PAA-TiO x NPs with free H 2 O 2 molecules to investigate the effect exerted on the radiosensitivity of cancer cells in vitro. A cell-free dialysis method revealed that a portion of the H 2 O 2 adsorbed onto the PAA-TiO x NPs during synthesis could be released during a treatment regimen. The H 2 O 2 release lasted for 7 h, which was sufficient for one radiation treatment procedure. For in vitro experiments, cultured human pancreatic cancer cells took up PAA-TiO x NPs in 10 min after administration. Interestingly, when the cells were washed with a buffer after treatment with either a PAA-TiO x NP or H 2 O 2 solution, the intracellular H 2 O 2 levels remained higher with PAA-TiO x NP treatment compared with the H 2 O 2 solution treatment. Furthermore, the effects of subsequent X-ray irradiation corresponded to the intracellular H 2 O 2 levels. These results indicate that PAA-TiO x NPs are efficient carriers of H 2 O 2 into cancer cells and thus enhance the radiosensitivity.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

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