Home-Based Physical Activity in Patients With Breast Cancer: During and/or After Chemotherapy? Impact on Cardiorespiratory Fitness. A 3-Arm Randomized Controlled Trial (APAC).

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Tytuł:: Home-Based Physical Activity in Patients With Breast Cancer: During and/or After Chemotherapy? Impact on Cardiorespiratory Fitness. A 3-Arm Randomized Controlled Trial (APAC).
Autorzy:: Vincent F; Department of Physiology, University Hospital, Limoges, France.; Faculty of Medicine, University of Limoges, Limoges, France.
Deluche E; Faculty of Medicine, University of Limoges, Limoges, France.; Department of Medical Oncology, University Hospital, Limoges, France.
Bonis J; Faculty of Medicine, University of Limoges, Limoges, France.
Leobon S; Department of Biostatistics and Clinical Research, University Hospital, Limoges, France.
Antonini MT; Department of Physiology, University Hospital, Limoges, France.
Laval C; Department of Physiology, University Hospital, Limoges, France.; Faculty of Medicine, University of Limoges, Limoges, France.
Favard F; Department of Physiology, University Hospital, Limoges, France.
Dobbels E; Department of Biostatistics and Clinical Research, University Hospital, Limoges, France.
Lavau-Denes S; Department of Biostatistics and Clinical Research, University Hospital, Limoges, France.
Labrunie A; Department of Biostatistics and Clinical Research, University Hospital, Limoges, France.
Thuillier F; Department of Biostatistics and Clinical Research, University Hospital, Limoges, France.
Venat L; Department of Biostatistics and Clinical Research, University Hospital, Limoges, France.
Tubiana-Mathieu N; Faculty of Medicine, University of Limoges, Limoges, France.; Department of Medical Oncology, University Hospital, Limoges, France.; Department of Biostatistics and Clinical Research, University Hospital, Limoges, France.
Źródło:: Integrative cancer therapies [Integr Cancer Ther] 2020 Jan-Dec; Vol. 19, pp. 1534735420969818.
Typ publikacji:: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Thousand Oaks, CA : Sage Publications, c2002-
MeSH Terms:: Breast Neoplasms*/drug therapy
Cardiorespiratory Fitness*
Exercise ; Exercise Therapy ; Female ; Humans ; Muscle Strength ; Physical Fitness ; Quality of Life ; Treatment Outcome
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Contributed Indexing:: Keywords: adapted physical activity; breast cancer; chemotherapy; home training; peak oxygen consumption
Molecular Sequence:: ClinicalTrials.gov NCT01795612
Entry Date(s):: Date Created: 20201124 Date Completed: 20210818 Latest Revision: 20210818
Update Code:: 20240105
PubMed Central ID:: PMC7691904
DOI:: 10.1177/1534735420969818
PMID:: 33228382
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Objectives: Physical activity (PA) programs are recommended for breast cancer care. However, their modalities remain to be discussed. This study determined the best time to begin a personalized or adapted program based on cardiopulmonary exercise test function. This randomized controlled trial evaluated the effect of home-based adapted PA (APA) performed during or after treatment on cardiorespiratory fitness (CRF) at 12 months.
Method: The primary endpoint was the peak oxygen consumption (VO 2peak ) at 12 months (group A vs C and B vs C). Secondary endpoints included the 6-minute walking test, assessment of muscle strength, fatigue, quality of life, anxiety, and depression, and a questionnaire on PA levels. All tests were evaluated at baseline and at 6 and 12 months. A total of 94 patients with breast cancer were randomized to 3 different groups: group A, performing 6 months of APA during adjuvant care; group B, 6 months of APA after adjuvant care; and group C, 12 months of APA during and after specific care. The program combined 1 resistance session and 2 aerobic sessions per week. Analysis of variance was used for repeated measures, Student's t -test or the Mann-Whitney U -test for continuous variables, and χ 2 test for binary or categorical variables.
Results: The study assessed 81 participants at 6 months and 73 at 12 months. The majority of patients completed more than 85% of the exercise sessions. The baseline for VO 2peak and secondary outcomes did not differ among the groups. VO 2peak increased during the exercise period and decreased during the chemotherapy period without APA, but at 12 months no significant difference was observed. The same variation was observed in the 6-minute walking test, with significance at 6 months between A+C versus B ( P = .04), but no difference among the groups at 12 months. In the 3 groups, no decreases in other studied parameters were noted, except at 6 months in group B without APA.
Conclusion: Home-based APA in breast cancer patients has a positive effect on CRF and physical functions, with no differences based on the timing of this program based on specific cancer treatment.
Trial Registration: ClinicalTrials.gouv.fr (NCT01795612). Registered 20 February 2013.

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