Impact of dehydroepiandrosterone on thyroid autoimmunity and function in men with autoimmune hypothyroidism.

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Tytuł:: Impact of dehydroepiandrosterone on thyroid autoimmunity and function in men with autoimmune hypothyroidism.
Autorzy:: Krysiak R; Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752, Katowice, Poland. .
Szkróbka W; Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752, Katowice, Poland.
Okopień B; Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752, Katowice, Poland.
Źródło:: International journal of clinical pharmacy [Int J Clin Pharm] 2021 Aug; Vol. 43 (4), pp. 998-1005. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Dordrecht : Springer
MeSH Terms:: Autoimmunity*
Hypothyroidism*/drug therapy
Aged ; Dehydroepiandrosterone ; Humans ; Male ; Thyroid Hormones ; Thyrotropin
References:: Caturegli P, Kimura H, Rocchi R, Rose NR. Autoimmune thyroid diseases. Curr Opin Rheumatol. 2007;19:44–8. (PMID: 10.1097/BOR.0b013e3280113d1a)
Brown RS. Autoimmune thyroid disease: unlocking a complex puzzle. Curr Opin Pediatr. 2009;21:523–8. (PMID: 10.1097/MOP.0b013e32832cf824)
Chen Y, Chen Y, Xia F, Wang N, Chen C, Nie X, et al. A higher ratio of estradiol to testosterone is associated with autoimmune thyroid disease in males. Thyroid. 2017;27:960–6. (PMID: 10.1089/thy.2016.0661)
Wortsman J, Rosner W, Dufau ML. Abnormal testicular function in men with primary hypothyroidism. Am J Med. 1987;82:207–12. (PMID: 10.1016/0002-9343(87)90057-X)
Doukas C, Saltiki K, Mantzou A, Cimponeriu A, Terzidis K, Sarika L, et al. Hormonal parameters and sex hormone receptor gene polymorphisms in men with autoimmune diseases. Rheumatol Int. 2013;34:575–82. (PMID: 10.1007/s00296-012-2386-4)
Krysiak R, Kowalcze K, Okopień B. The effect of testosterone on thyroid autoimmunity in euthyroid men with Hashimoto’s thyroiditis and low testosterone levels. J Clin Pharm Ther. 2019;44:742–9. (PMID: 10.1111/jcpt.12987)
Krysiak R, Kowalcze K, Okopień B. The effect of spironolactone onthyroidautoimmunity in euthyroid men with Hashimoto’s thyroiditis. J Clin Pharm Ther. 2020;45:152–9. (PMID: 10.1111/jcpt.13046)
Prall SP, Muehlenbein MP. DHEA modulates immune function: a review of evidence. Vitam Horm. 2018;108:125–44. (PMID: 10.1016/bs.vh.2018.01.023)
Drbalová K, Matucha P, Matejková-Behanová M, Bílek R, Kríz L, Kazihnitková H, et al. Immunoprotective steroids and SHBG in non-treated hypothyroidism and their relationship to autoimmune thyroid disorders. Physiol Res. 2008;57(Suppl 1):S119–25. (PMID: 10.33549/physiolres.931496)
Ott J, Pecnik P, Promberger R, Pils S, Seemann R, Hermann M, et al. Dehydroepiandrosterone in women with premature ovarian failure and Hashimoto’s thyroiditis. Climacteric. 2014;17:92–6. (PMID: 10.3109/13697137.2013.800040)
Jostel A, Ryder WD, Shalet SM. The use of thyroid function tests in the diagnosis of hypopituitarism: definition and evaluation of the TSH Index. Clin Endocrinol. 2009;71:529–34. (PMID: 10.1111/j.1365-2265.2009.03534.x)
Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH, Midgley JE, et al. Calculated parameters of thyroid homeostasis: emerging tools for differential diagnosis and clinical research. Front Endocrinol. 2016;7:57. (PMID: 10.3389/fendo.2016.00057)
Dietrich JW, Müller P, Schiedat F, Schlömicher M, Strauch J, Chatzitomaris A, et al. Nonthyroidal illness syndrome in cardiac illness involves elevated concentrations of 3,5-diiodothyronine and correlates with atrial remodeling. Eur Thyroid J. 2015;4:129–37. (PMID: 10.1159/000381543)
Merrill SJ, Minucci SB. Thyroid autoimmunity: an interplay of factors. Vitam Horm. 2018;106:129–45. (PMID: 10.1016/bs.vh.2017.07.001)
Vanderpump MP, Tunbridge WM. Epidemiology and prevention of clinical and subclinical hypothyroidism. Thyroid. 2002;12:839–47. (PMID: 10.1089/105072502761016458)
Colucci P, Yue CS, Ducharme M, Benvenga S. A review of the pharmacokinetics of levothyroxine for the treatment of hypothyroidism. Eur Endocrinol. 2013;9:40–7. (PMID: 10.17925/EE.2013.09.01.40)
Biondi B, Wartofsky L. Treatment with thyroid hormone. Endocr Rev. 2014;35:433–512. (PMID: 10.1210/er.2013-1083)
Papierska L, Rabijewski M. Delay in diagnosis of adrenal insufficiency is a frequent cause of adrenal crisis. Int J Endocrinol. 2013;2013:482370. (PMID: 10.1155/2013/482370)
Papi G, Uberti ED, Betterle C, Carani C, Pearce EN, Braverman LE, et al. Subclinical hypothyroidism. Curr Opin Endocrinol Diabetes Obes. 2007;14:197–208. (PMID: 10.1097/MED.0b013e32803577e7)
Floriani C, Gencer B, Collet TH, Rodondi N. Eur Heart J. Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update. 2018;39:503–7.
Webb SJ, Geoghegan TE, Prough RA, Miller MK. The biological actions of dehydroepiandrosterone involves multiple receptors. Drug Metab Rev. 2006;38:89–116. (PMID: 10.1080/03602530600569877)
Pelletier G. Localization of androgen and estrogen receptors in rat and primate tissues. Histol Histopathol. 2000;15:1261–70. (PMID: 11005250)
Gessl A, Lemmens-Gruber R, Kautzky-Willer A. Thyroid disorders. Handb Exp Pharmacol. 2012;214:361–86. (PMID: 10.1007/978-3-642-30726-3_17)
Hildebrand F, Pape HC, Hoevel P, Krettek C, van Griensven M. The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model. Shock. 2003;20:338–46. (PMID: 10.1097/01.shk.0000081408.57952.22)
Powell JM, Sonnenfeld G. The effects of dehydroepiandrosterone (DHEA) on in vitro spleen cell proliferation and cytokine production. J Interferon Cytokine Res. 2006;26:34–9. (PMID: 10.1089/jir.2006.26.34)
Krysiak R, Okopień B. The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 2011;96:2206–15. (PMID: 10.1210/jc.2010-2986)
Kłapcińska B, Poprzecki S, Danch A, Sobczak A, Kempa K. Selenium levels in blood of Upper Silesian population: evidence of suboptimal selenium status in a significant percentage of the population. Biol Trace Elem Res. 2005;108:1–15. (PMID: 10.1385/BTER:108:1-3:001)
Szybiński Z. Polish council for control of iodine deficiency disorders. Work of the Polish council for control of iodine deficiency disorders, and the model of iodine prophylaxis in Poland. Endokrynol Pol. 2012;63:156–60. (PMID: 22538756)
Contributed Indexing:: Keywords: Adrenal androgens; Hypothalamic-pituitary-thyroid axis; Thyroid autoimmunity; Thyroid function tests
Substance Nomenclature:: 0 (Thyroid Hormones)
459AG36T1B (Dehydroepiandrosterone)
9002-71-5 (Thyrotropin)
Entry Date(s):: Date Created: 20201127 Date Completed: 20211015 Latest Revision: 20211015
Update Code:: 20240105
DOI:: 10.1007/s11096-020-01207-w
PMID:: 33245519
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Background Testosterone administration was found to have a protective effect on thyroid autoimmunity in men with autoimmune (Hashimoto's) thyroiditis. Objective The present study was aimed at assessing whether oral dehydroepiandrosterone affects thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in men with subclinical hypothyroidism induced by Hashimoto's thyroiditis. Setting The study was conducted at Medical University of Silesia, Katowice, Poland. Method The study enrolled 32 elderly men with autoimmune hypothyroidism and low dehydroepiandrosterone-sulfate levels. Based on patient preference, the participants either received oral dehydroepiandrosterone (50 mg daily; n = 16) or remained untreated (n = 16). Apart from measuring antibody titers and hormone levels, we calculated baseline and post-treatment values of three structure parameters of thyroid homeostasis. Main outcome measure Serum titers of thyroid peroxidase and thyroglobulin antibodies. Results At baseline, there were no significant differences in the investigated parameters between both groups of men. All participants completed the study. Oral dehydroepiandrosterone increased dehydroepiandrosterone-sulfate and testosterone levels, as well as had a neutral effect on estradiol levels. The increase in dehydroepiandrosterone-sulfate correlated with treatment-induced changes in serum testosterone. Moreover, dehydroepiandrosterone reduced titers of thyroid peroxidase and thyroglobulin antibodies, decreased serum thyrotropin levels, reduced Jostel's thyrotropin index as well as increased thyroid's secretory capacity. Treatment-induced changes in thyroid antibody titers, thyrotropin levels, Jostel's thyrotropin index and thyroid's secretory capacity correlated with the increase in dehydroepiandrosterone-sulfate and testosterone levels. Conclusion The obtained results show that exogenous dehydroepiandrosterone may exert a beneficial effect on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in men with autoimmune thyroiditis and subclinical hypothyroidism.
(© 2020. Springer Nature Switzerland AG.)

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