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Tytuł pozycji:

Reduced coupling of somatosensory gating and gamma oscillation in panic disorder.

Tytuł:
Reduced coupling of somatosensory gating and gamma oscillation in panic disorder.
Autorzy:
Cheng CH; Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan. Electronic address: .
Liu CY; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Hsu SC; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation), Taiwan.
Tseng YJ; Department of Medical Research, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan.
Źródło:
Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2021 Jan 30; Vol. 307, pp. 111227. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: Amsterdam : Elsevier
MeSH Terms:
Panic Disorder*
Evoked Potentials, Somatosensory ; Humans ; Magnetoencephalography ; Sensory Gating ; Somatosensory Cortex
Contributed Indexing:
Keywords: Gamma oscillation; Inhibitory function; Magnetoencephalography (MEG); Primary somatosensory cortex (SI); Sensory gating
Entry Date(s):
Date Created: 20201128 Date Completed: 20210427 Latest Revision: 20210427
Update Code:
20240105
DOI:
10.1016/j.pscychresns.2020.111227
PMID:
33248324
Czasopismo naukowe
Previous studies have reported that patients with panic disorder (PD) exhibited an aberrant level of GABA concentration, an inhibitory neurotransmitter in the human brain. However, it remains substantially unclear whether the inhibitory function regarding the neurophysiological characteristics is altered in this disease. Sensory gating (SG) is considered as an automatic inhibitory function in the sensory cortex. In addition, brain's gamma oscillation within the sensory cortex is another index to reflect inhibitory function. Here we aimed to investigate whether the patients with PD showed altered inhibitory function in the somatosensory system, including the primary (SI) and secondary (SII) somatosensory cortices. A total of 20 healthy controls and 21 patients with PD underwent magnetoencephalographic recordings. Paired-pulse and single-pulse paradigms were used to study SG and gamma oscillations, respectively. There were no significant between-group differences in the SG function in the SI and SII. However, patients with PD demonstrated a reduced gamma power in the SI. Among the healthy individuals, strong associations between SG ratios and gamma frequency values were observed in the SI. However, such a functional relationship disappeared among the patients with PD. We suggested the reduced coupling of SG and gamma oscillation as one of the neural signatures in PD.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

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