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Tytuł:
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Potential emerging roles of the novel adipokines adipolin/CTRP12 and meteorin-like/METRNL in obesity-osteoarthritis interplay.
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Autorzy:
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Sobieh BH; Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: .
Kassem DH; Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: dina_.
Zakaria ZM; Orthopedic Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: .
El-Mesallamy HO; Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Faculty of Pharmacy, Sinai University, Sinai, Egypt. Electronic address: .
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Źródło:
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Cytokine [Cytokine] 2021 Feb; Vol. 138, pp. 155368. Date of Electronic Publication: 2020 Nov 25.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2001- > : Oxford : Elsevier Science Ltd.
Original Publication: [Philadelphia, PA] : Saunders Scientific Publications, W.B. Saunders, [c1989-
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MeSH Terms:
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Gene Expression Regulation*
Adipokines/*blood
Obesity/*blood
Osteoarthritis/*blood
Adipose Tissue/metabolism ; Adult ; Blood Glucose ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Insulin ; Insulin Resistance ; Knee/diagnostic imaging ; Male ; Matrix Metalloproteinase 13/blood ; Middle Aged ; Obesity/complications ; Osteoarthritis/complications ; X-Rays
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Contributed Indexing:
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Keywords: Adipokines; Adipolin; C1qdc2; CTRP12; Degenerative joint disease; Meteorin-like; Metrnl; Osteoarthritis; Subfatin
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Substance Nomenclature:
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0 (Adipokines)
0 (Blood Glucose)
0 (C1QTNF12 protein, human)
0 (Insulin)
0 (Metrnl protein, human)
EC 3.4.24.- (MMP13 protein, human)
EC 3.4.24.- (Matrix Metalloproteinase 13)
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Entry Date(s):
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Date Created: 20201129 Date Completed: 20220118 Latest Revision: 20220118
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Update Code:
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20240105
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DOI:
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10.1016/j.cyto.2020.155368
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PMID:
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33248913
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Background: Several insights into obesity-osteoarthritis (OA) relationship have been recently highlighted. Adipolin and metrnl are new adipokines also secreted by chondrocytes. However, their role in OA, and obesity-OA interplay hasn't been elucidated. Therefore, this study was designed to investigate the circulating as well as synovial fluid (SF) levels of adipolin and metrnl in osteoarthritic-patients compared to non-osteoarthritic subjects, and to study their association with OA-severity, dyslipidemia and insulin resistance (IR).
Methods: Patients with osteoarthritis and obesity (n = 30), and subjects with obesity not suffering OA (n = 25) were enrolled in the current study. Circulating and SF-levels of adipolin, metrnl, and insulin, as well as SF-levels of matrix-metalloproteinase-13 (MMP-13) were measured by ELISA. Knee-radiographs using X-ray were done to determine OA-severity, and investigate its association with adipokines' levels.
Results: Serum and SF-adipolin levels showed tendency to be lower in OA-patients compared to non-OA-subjects; serum: 0.64 [0.45-0.85] and 0.73 [0.62-0.78] ng/ml, p = 0.174, and SF: 0.53 [0.34-0.69] and 0.63 [0.44-0.74] ng/ml, p = 0.353, respectively. Additionally, serum adipolin showed negative-association with SF-MMP-13. However, when stratifying OA-patients into various severity grades, serum adipolin levels did not show a significant difference between them. Regarding serum metrnl, it was significantly lower in OA-patients compared to non-OA-subjects; 19.68 [10.40-53.40] and 48.83 [20.80-86.60] pg/ml, respectively, p = 0.018. Surprisingly, SF-metrnl levels were higher in OA-patients compared to non-OA-subjects; 912 [367-1524] and 315 [125-484] pg/ml, respectively, p = 0.007. SF-metrnl showed positive-association with insulin resistance, and negative-association with SF-MMP-13. Moreover, higher serum metrnl levels were found to be slightly associated with lower likelihood of OA in subjects with obesity; OR = 0.978, CI (0.960- 0.996), p = 0.02, and its levels were also found to be relatively lower in grade-4 compared to the less severe OAgrades.
Conclusions: Metrnl, and to a lesser extent adipolin seem to be interrelated with OA. Different in-context regulatory mechanisms for metrnl production from various tissues are strongly suggested. Importantly, the findings of the current study shed lights on metrnl as a potential novel mediator and therapeutic target to consider in obesity-OA interplay.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)