Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review.

Szczegóły
Abstrakt

Tytuł:: Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review.
Autorzy:: Tu TM; Department of Neurology, National Neuroscience Institute, Singapore.
Goh C; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Tan YK; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Leow AS; Division of Neurology, Department of Medicine, National University Health System, Singapore.
Pang YZ; Department of Neurology, National Neuroscience Institute, Singapore.
Chien J; Department of Neurology, National Neuroscience Institute, Singapore.
Shafi H; Department of Neurology, National Neuroscience Institute, Singapore.
Chan BP; Division of Neurology, Department of Medicine, National University Health System, Singapore.
Hui A; Division of Neurology, Department of Medicine, Ng Teng Fong General Hospital, Singapore.
Koh J; Department of Neurology, National Neuroscience Institute, Singapore.
Tan BY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Neurology, Department of Medicine, National University Health System, Singapore.
Umapathi NT; Department of Neurology, National Neuroscience Institute, Singapore.
Yeo LL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Neurology, Department of Medicine, National University Health System, Singapore. Electronic address: leonard_ll_.
Źródło:: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2020 Dec; Vol. 29 (12), pp. 105379. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji:: Case Reports; Journal Article; Systematic Review
Język:: English
Imprint Name(s):: Publication: Philadelphia, PA : Saunders
Original Publication: New York, NY : Demos Publications, [1991-
MeSH Terms:: COVID-19/*complications
Sinus Thrombosis, Intracranial/*etiology
Venous Thrombosis/*etiology
Adult ; Antibodies, Antiphospholipid/blood ; Anticoagulants/therapeutic use ; Biomarkers/blood ; C-Reactive Protein/analysis ; COVID-19/diagnosis ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Male ; Middle Aged ; Risk Factors ; Sinus Thrombosis, Intracranial/blood ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Sinus Thrombosis, Intracranial/drug therapy ; Treatment Outcome ; Venous Thrombosis/blood ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/drug therapy
References:: AJNR Am J Neuroradiol. 2020 Aug;41(8):1370-1376. (PMID: 32554424)
J Am Coll Cardiol. 2020 Jul 7;76(1):122-124. (PMID: 32387623)
Curr Cardiol Rep. 2014 Sep;16(9):523. (PMID: 25073867)
Stroke. 2016 Sep;47(9):2180-2. (PMID: 27435401)
J Thromb Haemost. 2020 Jul;18(7):1559-1561. (PMID: 32302453)
Thromb Res. 2020 Jul;191:9-14. (PMID: 32353746)
J Thromb Haemost. 2020 Aug;18(8):1995-2002. (PMID: 32369666)
J Thromb Haemost. 2020 May;18(5):1094-1099. (PMID: 32220112)
J Thromb Thrombolysis. 2020 Oct;50(3):587-595. (PMID: 32661757)
J Neuroradiol. 2021 Mar;48(2):121-124. (PMID: 32437707)
Rev Neurol (Paris). 2020 Jun;176(6):521-523. (PMID: 32414532)
Eur J Case Rep Intern Med. 2020 Apr 29;7(5):001691. (PMID: 32399457)
J Neurol Sci. 2020 Jul 15;414:116871. (PMID: 32422428)
J Thromb Haemost. 2020 Jul;18(7):1743-1746. (PMID: 32320517)
Lancet Infect Dis. 2020 Jul;20(7):773. (PMID: 32171390)
Thromb Res. 2020 Jul;191:148-150. (PMID: 32381264)
Stroke. 2020 Jul;51(7):e124-e127. (PMID: 32396456)
Stroke Vasc Neurol. 2020 Sep;5(3):279-284. (PMID: 32616524)
J Neurol Neurosurg Psychiatry. 2020 Aug;91(8):889-891. (PMID: 32354768)
Transl Stroke Res. 2020 Jun;11(3):322-325. (PMID: 32378030)
Rev Neurol. 2020 May 16;70(10):391-392. (PMID: 32390132)
Clin Neuroradiol. 2020 Dec;30(4):661-670. (PMID: 32529307)
Lancet Neurol. 2007 Feb;6(2):162-70. (PMID: 17239803)
Eur J Neurol. 2020 Sep;27(9):e38-e39. (PMID: 32503080)
J Thromb Haemost. 2020 Jul;18(7):1738-1742. (PMID: 32302438)
N Engl J Med. 2020 Apr 23;382(17):e38. (PMID: 32268022)
JAMA Neurol. 2020 Jun 1;77(6):683-690. (PMID: 32275288)
J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104989. (PMID: 32689590)
Contributed Indexing:: Keywords: Anticoagulation; Cerebral venous thrombosis; Coronavirus disease 2019; Mortality; Systematic review
Substance Nomenclature:: 0 (Antibodies, Antiphospholipid)
0 (Anticoagulants)
0 (Biomarkers)
0 (Fibrin Fibrinogen Degradation Products)
0 (fibrin fragment D)
9007-41-4 (C-Reactive Protein)
Entry Date(s):: Date Created: 20201201 Date Completed: 20201209 Latest Revision: 20231112
Update Code:: 20240105
PubMed Central ID:: PMC7538072
DOI:: 10.1016/j.jstrokecerebrovasdis.2020.105379
PMID:: 33254369
: Czasopismo naukowe

Full Text Finder

Background: There has been increasing reports associating the coronavirus disease 2019 (COVID-19) with thromboembolic phenomenon including ischemic strokes and venous thromboembolism. Cerebral venous thrombosis (CVT) is a rare neurovascular emergency that has been observed in some COVID-19 patients, yet much remains to be learnt of its underlying pathophysiology.
Objective: We present a case series of local patients with concomitant COVID-19 infection and CVT; and aim to perform a systematic review of known cases in the current literature.
Methods: We describe two patients with concomitant COVID-19 infection and CVT from a nationwide registry in Singapore. We then conducted a literature search in PubMed and Embase using a suitable keyword search strategy from 1st December 2019 to 11th June 2020. All studies reporting CVT in COVID-19 patients were included.
Results: Nine studies and 14 COVID-19 patients with CVT were studied. The median age was 43 years (IQR=36-58) and majority had no significant past medical conditions (60.0%). The time taken from onset of COVID-19 symptoms to CVT diagnosis was a median of 7 days (IQR=6-14). CVT was commonly seen in the transverse (75.0%) and sigmoid sinus (50.0%); 33.3% had involvement of the deep venous sinus system. A significant proportion of patients had raised D-dimer (75.0%) and CRP levels (50.0%). Two patients reported presence of antiphospholipid antibodies. Most patients received anticoagulation (91.7%) while overall mortality rate was 45.5%.
Conclusions: The high mortality rate of CVT in COVID-19 infection warrants a high index of suspicion from physicians, and early treatment with anticoagulation should be initiated.
Competing Interests: Declaration of Competing Interest There are no conflict of interests.
(Copyright © 2020 Elsevier Inc. All rights reserved.)

Informacja