Relations between vitamin D3, total and specific IgE for house dust mites in atopic dermatitis patients.

Tytuł:: Relations between vitamin D3, total and specific IgE for house dust mites in atopic dermatitis patients.
Autorzy:: Ibrahim HM; Dermatology, Andrology and Venereology, Qena Faculty of Medicine, South Valley University, Qena, 83523, Egypt. .
El-Taieb MA; Department of Dermatology, Andrology and Venereology, Aswan Faculty of Medicine, Aswan University, Tingar, Egypt.
Hassan MH; Department of Medical Biochemistry, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Mohamed AAE; Clinical Pathology, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Kotop EA; Dermatology, Venereology and Andrology, Qena University Hospital, South Valley University, Qena, Egypt.
Abd-Ellah OH; Parasitology Department, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Hegazy EM; Department of Dermatology, Andrology and Venereology, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Źródło:: Scientific reports [Sci Rep] 2020 Dec 02; Vol. 10 (1), pp. 21000. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Dermatitis, Atopic/*etiology
Immunoglobulin E/*immunology
Pyroglyphidae/*immunology
Vitamin D/*blood
Adolescent ; Animals ; Child ; Child, Preschool ; Cross-Sectional Studies ; Dermatitis, Atopic/immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin E/blood ; Infant ; Male ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/immunology
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Substance Nomenclature:: 1406-16-2 (Vitamin D)
37341-29-0 (Immunoglobulin E)
Entry Date(s):: Date Created: 20201203 Date Completed: 20210114 Latest Revision: 20210114
Update Code:: 20240104
PubMed Central ID:: PMC7710713
DOI:: 10.1038/s41598-020-77968-1
PMID:: 33268802
: Czasopismo naukowe

Pełny tekst

Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease. There are a lot of evidences on the importance of vitamin D and house dust mite (HDM) allergens in the etiology and course of AD. The objectives of this study are to evaluate the relation between vitamin D3 level and house dust mites (HDM) Dermatophagoidspecies sensitization in pathogenesis of atopic dermatitis. Cross-sectional design study was conducted on 50 atopic dermatitis patients. Blood analysis were done to determine level of vitamin D3, total IgE by fluorescent immunoassay & specific IgE for HDM (d1, d2) & other inhalant allergens by ELISA test. There was significant high negative correlation with the specific IgE for HDM (r = -0. 62, p < 0.001) and vitamin D3. & there was non-significant minimal negative correlation with the specific IgE and other inhalant allergens (r = - 0.10, p > 0.05). There was a statistically significant relation between level of vitamin D3 and atopic dermatitis severity and sensitization to HDM and other allergens.

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