Low frequency deep brain stimulation in the inferior colliculus ameliorates haloperidol-induced catalepsy and reduces anxiety in rats.

Tytuł:: Low frequency deep brain stimulation in the inferior colliculus ameliorates haloperidol-induced catalepsy and reduces anxiety in rats.
Autorzy:: Ihme H; Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University of Marburg, Marburg, Germany.
Schwarting RKW; Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University of Marburg, Marburg, Germany.; Center for Mind, Brain, and Behavior (CMBB), Marburg, Germany.
Melo-Thomas L; Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University of Marburg, Marburg, Germany.; Center for Mind, Brain, and Behavior (CMBB), Marburg, Germany.; Behavioral Neurosciences Institute (INeC), São Paulo, Brazil.
Źródło:: PloS one [PLoS One] 2020 Dec 04; Vol. 15 (12), pp. e0243438. Date of Electronic Publication: 2020 Dec 04 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Anxiety/*therapy
Catalepsy/*therapy
Deep Brain Stimulation/*methods
Animals ; Anxiety/chemically induced ; Anxiety/physiopathology ; Catalepsy/chemically induced ; Catalepsy/physiopathology ; Disease Models, Animal ; Haloperidol/toxicity ; Male ; Rats ; Rats, Wistar
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Substance Nomenclature:: J6292F8L3D (Haloperidol)
Entry Date(s):: Date Created: 20201204 Date Completed: 20210125 Latest Revision: 20210125
Update Code:: 20240104
PubMed Central ID:: PMC7717509
DOI:: 10.1371/journal.pone.0243438
PMID:: 33275614
: Czasopismo naukowe

Pełny tekst

Deep brain stimulation (DBS) of the colliculus inferior (IC) improves haloperidol-induced catalepsy and induces paradoxal kinesia in rats. Since the IC is part of the brain aversive system, DBS of this structure has long been related to aversive behavior in rats limiting its clinical use. This study aimed to improve intracollicular DBS parameters in order to avoid anxiogenic side effects while preserving motor improvements in rats. Catalepsy was induced by systemic haloperidol (0.5mg/kg) and after 60 min the bar test was performed during which a given rat received continuous (5 min, with or without pre-stimulation) or intermittent (5 x 1 min) DBS (30Hz, 200-600μA, pulse width 100μs). Only continuous DBS with pre-stimulation reduced catalepsy time. The rats were also submitted to the elevated plus maze (EPM) test and received either continuous stimulation with or without pre-stimulation, or sham treatment. Only rats receiving continuous DBS with pre-stimulation increased the time spent and the number of entries into the open arms of the EPM suggesting an anxiolytic effect. The present intracollicular DBS parameters induced motor improvements without any evidence of aversive behavior, pointing to the IC as an alternative DBS target to induce paradoxical kinesia improving motor deficits in parkinsonian patients.
Competing Interests: The authors have declared that no competing interests exist.

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