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Tytuł:
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C-Reactive Protein Levels Are Higher in Patients With Fusiform Intracranial Aneurysms: A Case-Control Study.
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Autorzy:
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Mota Telles JP; Division of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Rabelo NN; Division of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Junior JR; Division of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Teixeira MJ; Division of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Figueiredo EG; Division of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address: .
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Źródło:
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World neurosurgery [World Neurosurg] 2021 Feb; Vol. 146, pp. e896-e901. Date of Electronic Publication: 2020 Dec 03.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: New York : Elsevier
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MeSH Terms:
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Aneurysm, Ruptured/*metabolism
C-Reactive Protein/*metabolism
Inflammation/*metabolism
Intracranial Aneurysm/*metabolism
Subarachnoid Hemorrhage/*metabolism
Adult ; Aged ; Aneurysm, Ruptured/diagnostic imaging ; Aneurysm, Ruptured/epidemiology ; Angiography, Digital Subtraction ; Case-Control Studies ; Cerebral Angiography ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/metabolism ; Female ; Humans ; Hypertension/epidemiology ; Hypertension/metabolism ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/epidemiology ; Male ; Middle Aged ; Risk Factors ; Rupture, Spontaneous ; Smoking/epidemiology ; Smoking/metabolism ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/epidemiology
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Contributed Indexing:
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Keywords: Biomarker; C-reactive protein; Fusiform aneurysm; Inflammation; Intracranial aneurysm
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Substance Nomenclature:
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9007-41-4 (C-Reactive Protein)
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Entry Date(s):
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Date Created: 20201205 Date Completed: 20210702 Latest Revision: 20210702
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Update Code:
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20240104
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DOI:
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10.1016/j.wneu.2020.11.042
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PMID:
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33278646
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Background: Comprehending the risk factors that contribute to the formation of fusiform aneurysms (FAs) might provide some insight into treatment and prevention strategies. This case-control study aimed to compare the levels of serum C-reactive protein (CRP), as a biomarker, between patients with fusiform and saccular intracranial aneurysms.
Methods: We retrospectively analyzed medical records from 2010 to 2019. Thirty-five patients were identified as having FAs: 13 (37.1%) were ruptured, and 22 were unruptured. An age-matched sample of 70 controls (2:1) with saccular aneurysms was obtained from the same records: 36 (51.4%) ruptured and 34 unruptured.
Results: Patients with FAs had median CRP values of 0.61 mg/dL (IQR: 1.5), compared with 0.29 mg/dL (IQR: 0.42) in controls (P < 0.01). Within both the ruptured and the unruptured group, median CRP was higher in patients with FAs compared with controls (P < 0.01). Diabetes, smoking status, hypertension, and sex did not significantly influence CRP levels. Age-adjusted analyses showed that fusiform morphology was independently associated with higher CRP levels for unruptured aneurysms (OR 1.2, 95% CI 1.05-1.43), but not for ruptured aneurysms (OR 1.02, 95%CI 0.99-1.05).
Conclusions: CRP was higher in patients with FAs than controls, and it constituted an independent predictor of fusiform morphology for patients with unruptured aneurysms. Inflammation might be an especially important factor in FA formation and growth, and further studies could use this finding to design new treatment strategies.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
