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Tytuł:
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Association Between Carbon Monoxide Intoxication and Incidence of Ischemic Stroke: A Retrospective Nested Case-Control Study in South Korea.
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Autorzy:
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Kwak K; Department of Occupational and Environmental Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan, Gyeonggi-do 15355, Republic of Korea. Electronic address: .
Kim M; Department of Neurology, Ajou University Hospital, Suwon, Republic of Korea. Electronic address: .
Choi WJ; Department of Occupational and Environmental Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea. Electronic address: .
Ju YS; Department of Occupational and Environmental Medicine, National Medical Center, Seoul, Republic of Korea. Electronic address: .
Park JT; Department of Occupational and Environmental Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan, Gyeonggi-do 15355, Republic of Korea. Electronic address: .
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Źródło:
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Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2021 Feb; Vol. 30 (2), pp. 105496. Date of Electronic Publication: 2020 Dec 02.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Philadelphia, PA : Saunders
Original Publication: New York, NY : Demos Publications, [1991-
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MeSH Terms:
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Carbon Monoxide Poisoning/*epidemiology
Ischemic Stroke/*epidemiology
Adult ; Aged ; Carbon Monoxide Poisoning/diagnosis ; Databases, Factual ; Female ; Humans ; Incidence ; Ischemic Stroke/diagnosis ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Young Adult
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Contributed Indexing:
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Keywords: CO intoxication; CO poisoning; Carbon monoxide; Conditional logistic regression; Ischemic stroke; Nested case-control study; Retrospective cohort
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Entry Date(s):
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Date Created: 20201205 Date Completed: 20210125 Latest Revision: 20210125
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Update Code:
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20240104
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DOI:
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10.1016/j.jstrokecerebrovasdis.2020.105496
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PMID:
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33278806
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Objectives: Severe neurological sequelae occur in patients with carbon monoxide (CO) intoxication; however, whether the latter increases the long-term risk of developing ischemic stroke is unclear. We investigated the association between CO intoxication and ischemic stroke using data from the Korean National Health Information Database.
Materials and Methods: We performed a retrospective, nested case-control study of 27,984 individuals treated for CO intoxication and 27,984 sex- and age-matched controls. Initially, we calculated the overall incidence and hazard ratio (HR) of ischemic stroke using conditional logistic regression. Thereafter, we calculated the incidences and HRs according to covariates and follow-up periods.
Results: The CO intoxication group had a significantly higher risk of developing ischemic stroke than the control group (adjusted HR 2.31, 95% CI [confidence interval] = 2.01-2.65). Male sex (adjusted HR 2.73, 95% CI = 2.23-3.34), age <40 (adjusted HR 3.53, 95% CI = 2.15-5.82), low income (adjusted HR 2.55, 95% CI = 1.56-4.15), comorbidities (adjusted HR 2.59, 95% CI = 1.48-4.52), and current smokers (adjusted HR 3.55, 95% CI = 1.67-7.60) had a higher risk of ischemic stroke. The risk of ischemic stroke was highest within 2 years after CO intoxication (adjusted HR 7.47, 95% CI = 2.76-20.26), and even >6 years after, the risk remained significantly higher than in the control group (adjusted HR 1.84, 95% CI = 1.53-2.20).
Conclusions: CO intoxication and the long-term risk of ischemic stroke are associated.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
