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Tytuł:
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A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities.
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Autorzy:
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Feng J; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Zhao D; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Xu Q; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Liu X; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Zhou M; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Ye X; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Lin T; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Wang G; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Sun C; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Ding R; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Tian W; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
Chen H; Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.
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Źródło:
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Natural product research [Nat Prod Res] 2022 Jul; Vol. 36 (13), pp. 3309-3316. Date of Electronic Publication: 2020 Dec 08.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
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MeSH Terms:
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Cardiac Glycosides*
Ranunculaceae*/chemistry
Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Glycosides/pharmacology ; NF-kappa B ; Phenols/pharmacology ; Plant Extracts/chemistry
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Contributed Indexing:
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Keywords: Trollius chinensis Bunge; anti-inflammatory; antibacterial; phenolic glycoside
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
0 (Anti-Inflammatory Agents)
0 (Cardiac Glycosides)
0 (Glycosides)
0 (NF-kappa B)
0 (Phenols)
0 (Plant Extracts)
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Entry Date(s):
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Date Created: 20201208 Date Completed: 20220706 Latest Revision: 20220706
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Update Code:
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20240104
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DOI:
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10.1080/14786419.2020.1855166
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PMID:
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33289423
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A undescribed phenolic glycoside, trochinenol A ( 1 ), was isolated from the flowers of Trollius chinensis Bunge and the structure was identified by spectroscopic methods. Its anti-inflammatory and antibacterial effects were investigated by broth microdilution and NF-κB reporter gene assays. Consequently, compound 1 exhibited an appreciable effect against Staphylococcus aureus with the MIC value of 6.25 µg/mL. Besides, it showed moderate effect against TNFα-induced activation of NF-κB pathway.
