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Tytuł pozycji:

Maturation of T and B Lymphocytes in the Assessment of the Immune Status in COVID-19 Patients.

Tytuł:
Maturation of T and B Lymphocytes in the Assessment of the Immune Status in COVID-19 Patients.
Autorzy:
Kwiecień I; Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Rutkowska E; Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Kłos K; Department of Infectious Diseases and Allergology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Więsik-Szewczyk E; Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Jahnz-Różyk K; Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Rzepecki P; Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Chciałowski A; Department of Infectious Diseases and Allergology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Źródło:
Cells [Cells] 2020 Dec 05; Vol. 9 (12). Date of Electronic Publication: 2020 Dec 05.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI
MeSH Terms:
B-Lymphocytes/*cytology
CD4-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*cytology
COVID-19/*pathology
Adult ; Aged ; Aged, 80 and over ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; COVID-19/immunology ; COVID-19/virology ; Case-Control Studies ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification
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Contributed Indexing:
Keywords: B cells maturation; CD4+ cells; COVID-19; T cells maturation; central memory CD4+; effector CD8+ cells; flow cytometry; plasmablasts
Entry Date(s):
Date Created: 20201209 Date Completed: 20201216 Latest Revision: 20201226
Update Code:
20240104
PubMed Central ID:
PMC7762118
DOI:
10.3390/cells9122615
PMID:
33291439
Czasopismo naukowe
Cell response to novel coronavirus disease 19 (COVID-19) is currently a widely researched topic. The assessment of leukocytes population and the maturation of both B and T lymphocytes may be important in characterizing the immunological profile of COVID-19 patients. The aim of the present study was to evaluate maturation of B and T cells in COVID-19 patients with interstitial lesions on chest X-ray (COVID-19 X-ray (+)), without changes on X-ray (COVID-19 X-ray (-)) and in healthy control. The study group consisted of 23 patients divided on two groups: COVID-19 X-ray (+) n = 14 and COVID-19 X-ray (-) n = 9 and control n = 20. The flow cytometry method was performed. We observed a significantly higher percentage of plasmablasts and lower CD4+ lymphocytes in COVID-19 X-ray (+) patients than in COVID-19 X-ray (-) and control. In the COVID-19 X-ray (+) patients, there was a lower proportion of effector CD4+ T cells, naïve CD8+ T cells and higher central memory CD4+ cells and effector CD8+ T cells than control. The above results showed that the assessment of selected cells of B and T lymphocytes by flow cytometry can distinguish patients with COVID-19 and differentiate patients with and without changes on chest X-ray.
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