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Tytuł pozycji:

Revealing lipid droplets evolution at nanoscale under proteohormone stimulation by a BODIPY- hexylcarbazole derivative.

Tytuł :
Revealing lipid droplets evolution at nanoscale under proteohormone stimulation by a BODIPY- hexylcarbazole derivative.
Autorzy :
Liu X; School of Life Science, Anhui University, Hefei, 230601, PR China.
Lu X; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei, 230601, PR China.
Zhu T; School of Life Science, Anhui University, Hefei, 230601, PR China.
Wenli D; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei, 230601, PR China.
Zhenghui Y; Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, PR China.
Cao H; School of Life Science, Anhui University, Hefei, 230601, PR China.
Wang S; School of Life Science, Wuhan University, Wuhan, 430072, PR China.
Tian Y; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei, 230601, PR China.
Zhang Z; Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, PR China; CAS Center for Excellence in Nanoscience, Institute of Intelligent Machines, Chinese Academy of Science, Hefei, PR China.
Zhang R; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei, 230601, PR China.
De Souza SC; Department of Chemistry, University College London, London University College London, Gower Street, London, WC1E 6BT, UK.
Tian X; School of Life Science, Anhui University, Hefei, 230601, PR China; Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei, 230601, PR China; Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, PR China; Department of Chemistry, University College London, London University College London, Gower Street, London, WC1E 6BT, UK; Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and molecular imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, 610041, PR China. Electronic address: .
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Źródło :
Biosensors & bioelectronics [Biosens Bioelectron] 2021 Mar 01; Vol. 175, pp. 112871. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Oxford : Elsevier Advanced Technology
Original Publication: [Barking, Essex, England] : Elsevier Applied Science, 1989-
MeSH Terms :
Biosensing Techniques*
Lipid Droplets*/metabolism
Boron Compounds ; Lipid Metabolism ; Triglycerides
Contributed Indexing :
Keywords: BODIPY- Hexylcarbazole derivative; Lipid droplets ultrastructure; Proteohormone simulation; STED super-Resolution nanoscopy
Substance Nomenclature :
0 (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)
0 (Boron Compounds)
0 (Triglycerides)
Entry Date(s) :
Date Created: 20201210 Date Completed: 20210514 Latest Revision: 20210514
Update Code :
20210623
DOI :
10.1016/j.bios.2020.112871
PMID :
33298339
Czasopismo naukowe
Lipid droplets (LDs) ultrastructure progression under proteohormone stimulation provide valuable clues for understanding conditions associated with obesity and diabetes. Current available LDs probes either alter intra-LDs environments or lack photo-resistance; thus, this research domain is poorly understood. In this work, a N-B-O type BODIPY- hexylcarbazole derivative named BoCz-Lip was rationally designed while achieving specific LDs live-cell targeting. BoCz-Lip showed minimal impact on cell viability as well as internal LDs' protein, triglyceride and cholesterol level. Along with its good photostability, it can be used to monitor LDs evolution under super-resolution nanoscopy. More importantly, we concluded how proteohormone could influence LDs ultrastructure, offering a better understanding for correlating diseases at the nanoscale.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

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