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Tytuł pozycji:

Ten years of enhancing neuro-imaging genetics through meta-analysis: An overview from the ENIGMA Genetics Working Group.

Tytuł:
Ten years of enhancing neuro-imaging genetics through meta-analysis: An overview from the ENIGMA Genetics Working Group.
Autorzy:
Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; School of Psychology, University of Queensland, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.
Grasby KL; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.
Painter JN; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Colodro-Conde L; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; School of Psychology, University of Queensland, Brisbane, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.; Faculty of Psychology, University of Murcia, Murcia, Spain.
Bralten J; Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Hibar DP; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.; Personalized Healthcare, Genentech, Inc., South San Francisco, California, USA.
Lind PA; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Pizzagalli F; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.
Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.
Stein JL; Department of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Franke B; Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Martin NG; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.
Corporate Authors:
ENIGMA Genetics Working Group
Źródło:
Human brain mapping [Hum Brain Mapp] 2022 Jan; Vol. 43 (1), pp. 292-299. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Język:
English
Imprint Name(s):
Publication: New York : Wiley
Original Publication: New York : Wiley-Liss, c1993-
MeSH Terms:
Brain*/anatomy & histology
Brain*/diagnostic imaging
Genetics*
Genome-Wide Association Study*
Mental Disorders*/diagnostic imaging
Mental Disorders*/genetics
Mental Disorders*/pathology
Meta-Analysis as Topic*
Nervous System Diseases*/diagnostic imaging
Nervous System Diseases*/genetics
Nervous System Diseases*/pathology
Neuroimaging*
Humans ; Multicenter Studies as Topic
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Grant Information:
EB020403 United States NH NIH HHS; U54 EB020403 United States EB NIBIB NIH HHS
Contributed Indexing:
Keywords: GWAS; MRI; neuro-imaging genetics
Entry Date(s):
Date Created: 20201210 Date Completed: 20220328 Latest Revision: 20220328
Update Code:
20240104
PubMed Central ID:
PMC8675405
DOI:
10.1002/hbm.25311
PMID:
33300665
Czasopismo naukowe
Here we review the motivation for creating the enhancing neuroimaging genetics through meta-analysis (ENIGMA) Consortium and the genetic analyses undertaken by the consortium so far. We discuss the methodological challenges, findings, and future directions of the genetics working group. A major goal of the working group is tackling the reproducibility crisis affecting "candidate gene" and genome-wide association analyses in neuroimaging. To address this, we developed harmonized analytic methods, and support their use in coordinated analyses across sites worldwide, which also makes it possible to understand heterogeneity in results across sites. These efforts have resulted in the identification of hundreds of common genomic loci robustly associated with brain structure. We have found both pleiotropic and specific genetic effects associated with brain structures, as well as genetic correlations with psychiatric and neurological diseases.
(© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)

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