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Tytuł pozycji:

Risk assessment of predicted serum concentrations of bisphenol A in children and adults following treatment with dental composite restoratives, dental sealants, or orthodontic adhesives using physiologically based pharmacokinetic modeling.

Tytuł :
Risk assessment of predicted serum concentrations of bisphenol A in children and adults following treatment with dental composite restoratives, dental sealants, or orthodontic adhesives using physiologically based pharmacokinetic modeling.
Autorzy :
Bagley BD; 3M Corporate Toxicology and Environmental Science, 3M Center, St. Paul, MN, 55144-1000, USA. Electronic address: .
Smith JN; Exposure Science, Pacific Northwest National Laboratory, Richland, WA, 99352, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 93771, USA.
Teeguarden JG; Exposure Science, Pacific Northwest National Laboratory, Richland, WA, 99352, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 93771, USA.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2021 Mar; Vol. 120, pp. 104839. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: <2003>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press, [c1981-
Contributed Indexing :
Keywords: Bisphenol A (BPA); Bisphenol A glycidyl methacrylate (BisGMA); Dental; Extract; Orthodontic; PBPK model; Serum concentration
Entry Date(s) :
Date Created: 20201210 Latest Revision: 20210209
Update Code :
20210211
DOI :
10.1016/j.yrtph.2020.104839
PMID :
33301868
Czasopismo naukowe
Bisphenol A (BPA) is a chemical used to manufacture bisphenol A glycidyl methacrylate (BisGMA). BisGMA has been used for decades in dental composite restoratives, sealants, and adhesives. Based on published studies, exposure to low concentrations of BPA are possible from dental and orthodontic devices. The serum BPA concentrations arising from such devices and oral doses were predicted using a PBPK model in children and adult females based on 1) published extraction data for cured and uncured 3M ESPE Filtek Supreme Ultra Flowable, 3M ESPE Filtek Bulk Fill Restorative, and 3M ESPE Clinpro Sealant and 2) published 20% ethanol/water and water rinsate data following orthodontic application with 3M ESPE Transbond MIP Primer and 3M ESPE Transbond XT Adhesive. Predicted oral exposure to BPA arising from these dental and orthodontic devices is low (median <10 ng/treatment) and predicted serum BPA concentrations were also low (<10 -4  nM). Even the maximum predicted exposure in this study (533.2 ng/treatment) yields a margin of exposure of 7.5 relative to the EFSA t-TDI (4 μg/kg-day) and is only 2.8% of the daily BPA exposure for the US population in a 58-kg woman (15,660 ng/day). Therefore, the exposure to BPA arising from the 3M ESPE dental and orthodontic devices evaluated in this study is negligible relative to daily BPA exposure in the general population and these potential BPA sources do not constitute a risk to patients.
(Copyright © 2021 Elsevier Inc., 3M Company. Published by Elsevier Inc. All rights reserved.)

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