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Tytuł:
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Chronic prepartum light-dark phase shifts in cattle disrupt circadian clocks, decrease insulin sensitivity and mammary development, and are associated with lower milk yield through 60 days postpartum.
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Autorzy:
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McCabe CJ; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907.
Suarez-Trujillo A; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907.
Teeple KA; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907.
Casey TM; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907. Electronic address: .
Boerman JP; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907. Electronic address: .
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Źródło:
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Journal of dairy science [J Dairy Sci] 2021 Feb; Vol. 104 (2), pp. 2422-2437. Date of Electronic Publication: 2020 Dec 11.
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Typ publikacji:
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Clinical Trial, Veterinary; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Champaign, IL : American Dairy Science Association
Original Publication: Lancaster, Pa. [etc.]
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MeSH Terms:
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Cattle*
Circadian Clocks*
Insulin Resistance*
Milk*
Postpartum Period*
Mammary Glands, Animal/*growth & development
3-Hydroxybutyric Acid/blood ; Animals ; Blood Glucose/metabolism ; Darkness ; Fatty Acids, Nonesterified/blood ; Female ; Glucose Tolerance Test/veterinary ; Insulin/blood ; Lactation/physiology ; Light ; Parturition ; Pregnancy
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Contributed Indexing:
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Keywords: circadian disruption; insulin sensitivity; mammary development
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Substance Nomenclature:
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0 (Blood Glucose)
0 (Fatty Acids, Nonesterified)
0 (Insulin)
TZP1275679 (3-Hydroxybutyric Acid)
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Entry Date(s):
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Date Created: 20201214 Date Completed: 20210315 Latest Revision: 20210315
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Update Code:
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20240104
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DOI:
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10.3168/jds.2020-19250
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PMID:
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33309361
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Circadian and metabolic systems are interlocked and reciprocally regulated. To determine if the circadian system regulates glucose homeostasis and mammary development, the function of the circadian system was disrupted by exposing cattle to chronic light-dark cycle phase shifts from 5 wk before expected calving (BEC) to parturition. Multiparous Holstein cows were exposed to 16 h of light and 8 h of dark (CON, n = 8) or phase shifting (PS, n = 8) the light cycle 6 h every 3 d beginning 35 d BEC. After calving, both treatments were exposed to CON lighting. Mammary biopsies were taken at 21 d BEC and 21 d in milk (DIM), and histological analysis indicated PS treatment decreased the ratio of lumen to alveolar area and percentage of proliferating epithelial cells in the prepartum period. Intravenous glucose tolerance test was performed at 14 d BEC and 7 DIM by administering 50% dextrose. Blood glucose, β-hydroxybutyrate, insulin, and nonesterified fatty acids were consequently measured over 3 h. At 14 d BEC no treatment differences were observed in baseline glucose or insulin. Treatment had no effect on blood glucose or glucose area under the curve at 14 d BEC and 7 DIM. Insulin area under the curve was higher in PS versus CON at 14 d BEC and 7 DIM. The PS cows produced less milk than CON cows through 60 DIM (40.3 vs. 42.6 kg/d). Exposure to chronic light-dark PS in late gestation decreased mammary development and increased insulin resistance in periparturient cows, which may have caused subsequent lower milk yield.
(The Authors. Published by Elsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).)