D-mannose suppresses macrophage IL-1β production.

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Abstrakt

Tytuł:: D-mannose suppresses macrophage IL-1β production.
Autorzy:: Torretta S; Cancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Scagliola A; Cancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Ricci L; Cancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Mainini F; Cancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Di Marco S; Cancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Cuccovillo I; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Kajaste-Rudnitski A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Sumpton D; CRUK Beatson Institute, Glasgow, UK.
Ryan KM; CRUK Beatson Institute, Glasgow, UK.
Cardaci S; Cancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy. .
Źródło:: Nature communications [Nat Commun] 2020 Dec 11; Vol. 11 (1), pp. 6343. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [London] : Nature Pub. Group
MeSH Terms:: Interleukin-1beta/*metabolism
Macrophage Activation/*drug effects
Macrophages/*drug effects
Macrophages/*metabolism
Mannose/*metabolism
Mannose/*pharmacology
Animals ; Cell Differentiation/drug effects ; Cell Line ; Colitis/metabolism ; Colitis/pathology ; Gene Expression Regulation ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Inflammation/metabolism ; Interleukin-1beta/genetics ; Lipopolysaccharides/adverse effects ; Mannosephosphates/metabolism ; Metabolic Networks and Pathways/drug effects ; Metabolomics ; Monocytes/metabolism
References:: Front Immunol. 2018 Mar 02;9:426. (PMID: 29552018)
Cell Stem Cell. 2018 Dec 6;23(6):820-832.e9. (PMID: 30416070)
Mucosal Immunol. 2019 Jan;12(1):178-187. (PMID: 30279517)
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11036-11041. (PMID: 30297433)
World J Urol. 2014 Feb;32(1):79-84. (PMID: 23633128)
Science. 2017 May 5;356(6337):513-519. (PMID: 28473584)
Nat Med. 2017 Sep;23(9):1036-1045. (PMID: 28759052)
Nat Metab. 2019 Jan;1:16-33. (PMID: 31032474)
Cell Metab. 2017 Jul 5;26(1):49-70. (PMID: 28683294)
Nat Rev Immunol. 2016 Sep;16(9):553-65. (PMID: 27396447)
Nat Rev Gastroenterol Hepatol. 2019 Sep;16(9):531-543. (PMID: 31312042)
Antioxid Redox Signal. 2020 Apr 20;32(12):834-852. (PMID: 31847530)
Dis Model Mech. 2018 Jul 30;11(7):. (PMID: 29967068)
Biochem Biophys Res Commun. 2014 Oct 17;453(2):220-8. (PMID: 24931670)
Cell Metab. 2019 Apr 2;29(4):1003-1011.e4. (PMID: 30773464)
Nat Immunol. 2019 Aug;20(8):970-979. (PMID: 31235952)
Cell. 2018 Aug 9;174(4):780-784. (PMID: 30096309)
J Biol Chem. 2006 Mar 3;281(9):5916-27. (PMID: 16339137)
Nature. 2013 Apr 11;496(7444):238-42. (PMID: 23535595)
Nat Commun. 2019 Nov 8;10(1):5091. (PMID: 31704924)
Cell. 2017 Feb 9;168(4):657-669. (PMID: 28187287)
Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):599-608. (PMID: 22907164)
Nat Chem Biol. 2019 Oct;15(10):983-991. (PMID: 31332308)
Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1564-9. (PMID: 26811453)
J Immunol. 2007 Jun 15;178(12):7516-9. (PMID: 17548584)
J Exp Med. 2016 Aug 22;213(9):1655-62. (PMID: 27481132)
Cell Mol Life Sci. 2018 Jun;75(12):2093-2109. (PMID: 29502308)
Sci Transl Med. 2010 Nov 17;2(58):58ra84. (PMID: 21084719)
PLoS One. 2017 Dec 20;12(12):e0190074. (PMID: 29261815)
Cell Rep. 2018 Sep 18;24(12):3087-3098. (PMID: 30231992)
Front Microbiol. 2018 Sep 25;9:2247. (PMID: 30319571)
Gut. 2015 Apr;64(4):589-600. (PMID: 24848264)
Mol Ther. 2014 Aug;22(8):1472-1483. (PMID: 24869932)
Nat Rev Drug Discov. 2019 Sep;18(9):669-688. (PMID: 31363227)
Front Immunol. 2018 Sep 03;9:1973. (PMID: 30233578)
Cell Stem Cell. 2018 Mar 1;22(3):355-368.e13. (PMID: 29478844)
Annu Rev Immunol. 2005;23:901-44. (PMID: 15771589)
Nature. 2018 Nov;563(7733):719-723. (PMID: 30464341)
Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13249-54. (PMID: 11606779)
Science. 2018 Apr 27;360(6387):449-453. (PMID: 29599194)
Immunity. 2018 Jan 16;48(1):75-90.e6. (PMID: 29343442)
World J Gastroenterol. 2017 Sep 7;23(33):6016-6029. (PMID: 28970718)
J Exp Med. 2012 Aug 27;209(9):1595-609. (PMID: 22891275)
Cell. 2016 Oct 6;167(2):457-470.e13. (PMID: 27667687)
Mol Cell. 2019 Sep 19;75(6):1147-1160.e5. (PMID: 31420217)
Grant Information:: 15816 United Kingdom CRUK_ Cancer Research UK; 22903 United Kingdom CRUK_ Cancer Research UK; A17196 United Kingdom CRUK_ Cancer Research UK; A22903 United Kingdom CRUK_ Cancer Research UK
Substance Nomenclature:: 0 (HIF1A protein, human)
0 (Hypoxia-Inducible Factor 1, alpha Subunit)
0 (IL1B protein, human)
0 (Interleukin-1beta)
0 (Lipopolysaccharides)
0 (Mannosephosphates)
3672-15-9 (mannose-6-phosphate)
PHA4727WTP (Mannose)
Entry Date(s):: Date Created: 20201214 Date Completed: 20210104 Latest Revision: 20240210
Update Code:: 20240210
PubMed Central ID:: PMC7733482
DOI:: 10.1038/s41467-020-20164-6
PMID:: 33311467
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D-mannose is a monosaccharide approximately a hundred times less abundant than glucose in human blood. Previous studies demonstrated that supraphysiological levels of D-mannose inhibit tumour growth and stimulate regulatory T cell differentiation. It is not known whether D-mannose metabolism affects the function of non-proliferative cells, such as inflammatory macrophages. Here, we show that D-mannose suppresses LPS-induced macrophage activation by impairing IL-1β production. In vivo, mannose administration improves survival in a mouse model of LPS-induced endotoxemia as well as decreases progression in a mouse model of DSS-induced colitis. Phosphomannose isomerase controls response of LPS-activated macrophages to D-mannose, which impairs glucose metabolism by raising intracellular mannose-6-phosphate levels. Such alterations result in the suppression of succinate-mediated HIF-1α activation, imposing a consequent reduction of LPS-induced Il1b expression. Disclosing an unrecognized metabolic hijack of macrophage activation, our study points towards safe D-mannose utilization as an effective intervention against inflammatory conditions.

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