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Tytuł pozycji:

Burkholderia ubonensis High-Level Tetracycline Resistance Is Due to Efflux Pump Synergy Involving a Novel TetA(64) Resistance Determinant.

Tytuł:
Burkholderia ubonensis High-Level Tetracycline Resistance Is Due to Efflux Pump Synergy Involving a Novel TetA(64) Resistance Determinant.
Autorzy:
Somprasong N; Department of Molecular Genetics & Microbiology, College of Medicine, Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Hall CM; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Webb JR; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Sahl JW; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Wagner DM; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Keim P; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Currie BJ; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.; Department of Infectious Diseases and Northern Territory Medical Program, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
Schweizer HP; Department of Molecular Genetics & Microbiology, College of Medicine, Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA .
Źródło:
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Feb 17; Vol. 65 (3). Date of Electronic Publication: 2021 Feb 17 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Język:
English
Imprint Name(s):
Original Publication: Washington, American Society for Microbiology
MeSH Terms:
Burkholderia cepacia complex*/genetics
Tetracycline*/pharmacology
Anti-Bacterial Agents/pharmacology ; Burkholderia ; Humans ; Tetracycline Resistance/genetics
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Contributed Indexing:
Keywords: Burkholderia; efflux pump; resistance; synergy; tetA(64); tetracycline
Substance Nomenclature:
0 (Anti-Bacterial Agents)
F8VB5M810T (Tetracycline)
SCR Organism:
Burkholderia multivorans; Burkholderia ubonensis
Entry Date(s):
Date Created: 20201215 Date Completed: 20210617 Latest Revision: 20210818
Update Code:
20240104
PubMed Central ID:
PMC8092502
DOI:
10.1128/AAC.01767-20
PMID:
33318011
Czasopismo naukowe
Burkholderia ubonensis , a nonpathogenic soil bacterium belonging to the Burkholderia cepacia complex (Bcc), is highly resistant to some clinically significant antibiotics. The concern is that B. ubonensis may serve as a resistance reservoir for Bcc or B. pseudomallei complex (Bpc) organisms that are opportunistic human pathogens. Using a B. ubonensis strain highly resistant to tetracycline (MIC, ≥256 µg/ml), we identified and characterized tetA (64) that encodes a novel tetracycline-specific efflux pump of the major facilitator superfamily. TetA(64) and associated TetR(64) regulator expression are induced by tetracyclines. Although TetA(64) is the primary tetracycline and doxycycline resistance determinant, maximum tetracycline and doxycycline resistance requires synergy between TetA(64) and the nonspecific AmrAB-OprA resistance nodulation cell division efflux pump. TetA(64) does not efflux minocycline, tigecycline, and eravacycline. Comprehensive screening of genome sequences showed that TetA(64) is unequally distributed in the Bcc and absent from the Bpc. It is present in some major cystic fibrosis pathogens, like Burkholderia cenocepacia , but absent from others like Burkholderia multivorans The tetR (64)- tetA (64) genes are located in a region of chromosome 1 that is highly conserved in Burkholderia sp. Because there is no evidence for transposition, the tetR (64)- tetA (64) genes may have been acquired by homologous recombination after horizontal gene transfer. Although Burkholderia species contain a resident multicomponent efflux pump that allows them to respond to tetracyclines up to a certain concentration, the acquisition of the single-component TetA(64) by some species likely provides the synergy that these bacteria need to defend against high tetracycline concentrations in niche environments.
(Copyright © 2021 American Society for Microbiology.)

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