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Tytuł:
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Exacerbation of antimicrobial resistance: another casualty of the COVID-19 pandemic?
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Autorzy:
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Razzaque MS; Professor of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.
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Źródło:
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Expert review of anti-infective therapy [Expert Rev Anti Infect Ther] 2021 Aug; Vol. 19 (8), pp. 967-971. Date of Electronic Publication: 2020 Dec 23.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: 2015- : Abingdon, Oxford : Taylor & Francis
Original Publication: London : Future Drugs Ltd.
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MeSH Terms:
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COVID-19*
Drug Resistance, Microbial*
Pandemics*
Anti-Bacterial Agents ; Bacteria/drug effects ; Drug Repositioning ; Drug Resistance, Bacterial ; Humans ; Quorum Sensing
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Contributed Indexing:
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Keywords: Antibiotics; antimicrobial drug resistance; quorum quenching; quorum sensing
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
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Entry Date(s):
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Date Created: 20201216 Date Completed: 20210805 Latest Revision: 20210805
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Update Code:
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20240105
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DOI:
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10.1080/14787210.2021.1865802
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PMID:
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33322965
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Introduction : The widespread use of antimicrobial drugs during the ongoing coronavirus disease 2019 (COVID-19) pandemic and the likely emergence of antibiotic-resistant microorganisms is a global health concern. Even before the COVID-19 pandemic, several antimicrobial drugs have lost their efficacy and are no longer useful to treat life-threatening infections. Since the exacerbation of antimicrobial resistance is likely to be another casualty of the COVID-19 pandemic, there is a pressing need to develop innovative strategies to minimize the risk of antimicrobial resistance. Areas covered : Focusing on the COVID-19 pandemic, I have briefly summarized the current knowledge and challenges in our understanding of antimicrobial resistance, emphasizing quorum sensing and quorum quenching. Our understanding of bacterial communication by quorum sensing to acquire virulence has paved the way to reduce bacterial pathogenicity through quorum quenching. Availability of clinically viable quorum quenching agents would likely to diminish bacterial virulence to create a microenvironment for the host phagocytic cells to reduce bacterial infection. Expert opinion : Future studies that aim to generate clinically useful quorum quenching agents need to be considered. An important benefit of such agents may be a diminished risk of antimicrobial resistance.