Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India.

Tytuł:: Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India.
Autorzy:: Kan CK; Section of Infectious Diseases, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America.
Ragan EJ; Section of Infectious Diseases, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America.
Sarkar S; Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Gorimedu, Puducherry, India.
Knudsen S; Section of Infectious Diseases, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America.
Forsyth M; Section of Infectious Diseases, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America.
Muthuraj M; Intermediate Reference Laboratory, Government Hospital for Chest Diseases, Gorimedu, Puducherry, India.
Vinod K; Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Gorimedu, Puducherry, India.
Jenkins HE; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Horsburgh CR; Section of Infectious Diseases, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.; Departments of Epidemiology and Global Health, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Salgame P; Division of Infectious Diseases, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America.
Roy G; Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Gorimedu, Puducherry, India.
Ellner JJ; Division of Infectious Diseases, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America.
Jacobson KR; Section of Infectious Diseases, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America.
Sahu S; Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Gorimedu, Puducherry, India.
Hochberg NS; Section of Infectious Diseases, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America.
Źródło:: PloS one [PLoS One] 2020 Dec 17; Vol. 15 (12), pp. e0240595. Date of Electronic Publication: 2020 Dec 17 (Print Publication: 2020).
Typ publikacji:: Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Alcohol Drinking/*epidemiology
Alcoholism/*epidemiology
Tuberculosis, Pulmonary/*epidemiology
Adolescent ; Adult ; Alcohol Drinking/adverse effects ; Alcoholism/complications ; Female ; Humans ; India ; Lung/diagnostic imaging ; Male ; Middle Aged ; Mycobacterium tuberculosis/isolation & purification ; Prospective Studies ; Radiography ; Risk Factors ; Severity of Illness Index ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/microbiology ; Young Adult
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Entry Date(s):: Date Created: 20201217 Date Completed: 20210119 Latest Revision: 20210119
Update Code:: 20240105
PubMed Central ID:: PMC7746146
DOI:: 10.1371/journal.pone.0240595
PMID:: 33332367
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Pełny tekst

Setting: Alcohol use increases the risk of tuberculosis (TB) disease and is associated with worse outcomes.
Objective: To determine whether alcohol use affects TB severity at diagnosis in a high-burden setting.
Design: Participants were smear-positive people living with TB (PLWTB) in India. Disease severity was assessed as 1) high versus low smear grade, 2) time to positivity (TTP) on liquid culture, 3) chest radiograph cavitation, and 4) percent lung affected. Alcohol use and being at-risk for alcohol use disorders (AUD) were assessed using the AUDIT-C. Univariable and multivariable analyses were conducted.
Results: Of 1166 PLWTB, 691 (59.3%) were drinkers; of those, 518/691 (75.0%) were at-risk for AUD. Drinkers had more lung affected than non-drinkers (adjusted mean difference 10.8%, p<0.0001); this was not significant for those at-risk for AUD (adjusted mean difference 3.7%, p = 0.11). High smear grade (aOR 1.0, 95%CI: 0.7-1.4), cavitation (aOR 0.8, 95%CI 0.4-1.8), and TTP (mean difference 5.2 hours, p = 0.51) did not differ between drinkers and non-drinkers, nor between those at-risk and not at-risk for AUD.
Conclusions: A large proportion of PLWTB were drinkers and were at-risk for AUD. Alcohol drinkers had more lung affected than non-drinkers. Studies are needed to explore mechanisms of this association.
Competing Interests: The authors have declared that no competing interests exist.

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