RNA-sequencing reveals transcriptional signature of pathological remodeling in the diaphragm of rats after myocardial infarction.

Szczegóły
Abstrakt

Tytuł:: RNA-sequencing reveals transcriptional signature of pathological remodeling in the diaphragm of rats after myocardial infarction.
Autorzy:: Yegorova S; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. Electronic address: .
Yegorov O; Department of Neurosurgery, University of Florida, Gainesville, FL 32611, USA. Electronic address: .
Ferreira LF; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. Electronic address: .
Źródło:: Gene [Gene] 2021 Feb 20; Vol. 770, pp. 145356. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Amsterdam, Elsevier/North-Holland, 1976-
MeSH Terms:: RNA-Seq*
Transcriptome*
Diaphragm/*metabolism
Muscle Proteins/*biosynthesis
Myocardial Infarction/*metabolism
Animals ; Diaphragm/pathology ; Male ; Myocardial Infarction/genetics ; Myocardial Infarction/pathology ; Rats ; Rats, Sprague-Dawley
References:: J Am Coll Cardiol. 1996 Aug;28(2):391-5. (PMID: 8800115)
Chest. 2001 Jun;119(6):1755-60. (PMID: 11399702)
Ciba Found Symp. 1984;108:163-78. (PMID: 6097420)
Annu Rev Biochem. 1992;61:157-97. (PMID: 1353950)
Curr Opin Nephrol Hypertens. 2008 Sep;17(5):526-32. (PMID: 18695395)
Muscle Nerve. 2011 Sep;44(3):318-31. (PMID: 21949456)
J Biol Chem. 2003 Jan 3;278(1):444-53. (PMID: 12401811)
Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L679-L690. (PMID: 30702345)
Innate Immun. 2018 Aug;24(6):335-348. (PMID: 30049243)
J Biol Chem. 2009 Oct 2;284(40):27025-9. (PMID: 19636077)
Biol Open. 2016 May 15;5(5):556-62. (PMID: 27069251)
Exp Neurol. 2013 Sep;247:101-9. (PMID: 23583688)
Connect Tissue Res. 2021 Jan;62(1):24-39. (PMID: 32664808)
Novartis Found Symp. 2002;247:91-101; discussion 101-3, 119-28, 244-52. (PMID: 12539951)
Heart Fail Monit. 2000;1(2):50-6. (PMID: 12634874)
J Mol Cell Cardiol. 2020 Feb;139:238-249. (PMID: 32035137)
Curr Opin Clin Nutr Metab Care. 2012 May;15(3):233-9. (PMID: 22366923)
Skelet Muscle. 2015 Jul 15;5:22. (PMID: 26180627)
Neural Regen Res. 2014 Oct 15;9(20):1796-809. (PMID: 25422641)
Precis Clin Med. 2018 Jun;1(1):49-56. (PMID: 35694127)
J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):1102-1115. (PMID: 31140761)
Am J Respir Crit Care Med. 1998 Dec;158(6):1963-7. (PMID: 9847293)
Biochim Biophys Acta. 2006 Dec;1763(12):1413-26. (PMID: 17028011)
Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb;5(1):55-71. (PMID: 23188744)
Ann Neurol. 2013 Dec;74(6):914-9. (PMID: 23798481)
Am J Physiol Lung Cell Mol Physiol. 2015 Sep 1;309(5):L497-505. (PMID: 26209274)
J Appl Physiol (1985). 2005 Sep;99(3):1078-84. (PMID: 16103520)
Physiol Genomics. 2007 Sep 19;31(1):86-95. (PMID: 17550994)
J Appl Physiol (1985). 2017 Mar 1;122(3):571-579. (PMID: 27979985)
Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1622-7. (PMID: 24474789)
Arch Biochem Biophys. 2011 Jun 15;510(2):120-8. (PMID: 21284933)
Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C392-403. (PMID: 27510905)
Physiol Genomics. 2012 Apr 15;44(8):443-54. (PMID: 22353257)
J Physiol. 2011 Nov 15;589(Pt 22):5485-501. (PMID: 21946849)
J Cell Biol. 1995 Dec;131(5):1341-9. (PMID: 8522594)
Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1260-8. (PMID: 18424622)
PLoS Biol. 2012 Feb;10(2):e1001264. (PMID: 22347814)
J Invest Dermatol. 2009 Mar;129(3):765-9. (PMID: 18818677)
J Pharmacol Exp Ther. 1999 Oct;291(1):70-5. (PMID: 10490888)
Compr Physiol. 2017 Jun 18;7(3):891-944. (PMID: 28640448)
J Clin Endocrinol Metab. 2016 Mar;101(3):1282-9. (PMID: 26765579)
Circ Res. 2010 Mar 19;106(5):880-90. (PMID: 20093627)
Biochim Biophys Acta. 2012 Feb;1823(2):316-26. (PMID: 22178386)
J Am Heart Assoc. 2015 Jul 31;4(8):e002272. (PMID: 26231844)
Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H819-28. (PMID: 17449557)
J Cell Sci. 2010 Sep 15;123(Pt 18):3052-60. (PMID: 20736301)
Eur J Heart Fail. 2014 May;16(5):519-25. (PMID: 24596158)
J Appl Physiol (1985). 2012 Dec 15;113(12):1884-901. (PMID: 23085959)
J Mol Cell Cardiol. 2015 Jul;84:70-80. (PMID: 25886697)
Exp Cell Res. 2018 Feb 15;363(2):227-234. (PMID: 29331388)
Cell Mol Life Sci. 2015 Mar;72(6):1029-43. (PMID: 25359233)
Heart Fail Rev. 2017 Mar;22(2):191-207. (PMID: 27000754)
PLoS One. 2013 Apr 18;8(4):e62347. (PMID: 23638045)
Am J Physiol. 1992 Aug;263(2 Pt 1):C429-35. (PMID: 1325116)
J Metabonomics Metab. 2012 Oct 15;1(1):. (PMID: 25346931)
J Biol Chem. 2008 Apr 25;283(17):11575-85. (PMID: 18303026)
Circulation. 2019 Mar 5;139(10):e56-e528. (PMID: 30700139)
Am J Physiol Heart Circ Physiol. 2012 Aug 15;303(4):H475-85. (PMID: 22707558)
BMC Genomics. 2007 Oct 19;8:379. (PMID: 17949489)
FASEB J. 2017 Feb;31(2):840-851. (PMID: 27856557)
EMBO Mol Med. 2016 Dec 1;8(12):1390-1408. (PMID: 27861123)
Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1637-44. (PMID: 21335475)
J Cardiovasc Magn Reson. 2000;2(3):171-80. (PMID: 11545114)
J Appl Physiol (1985). 2008 Jan;104(1):288-95. (PMID: 17962569)
Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E28-37. (PMID: 19066317)
J Cachexia Sarcopenia Muscle. 2012 Sep;3(3):157-62. (PMID: 22589021)
J Appl Physiol (1985). 2005 Feb;98(2):680-9. (PMID: 15475595)
Int J Cardiol. 2011 Jul 15;150(2):182-5. (PMID: 20444510)
Essays Biochem. 2005;41:173-86. (PMID: 16250905)
J Biol Chem. 2007 Jul 13;282(28):20447-54. (PMID: 17504755)
Can J Physiol Pharmacol. 2018 Mar;96(3):221-226. (PMID: 28787581)
Discoveries (Craiova). 2014 Apr-Jun;2(2):e15. (PMID: 26539561)
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11929-34. (PMID: 26351669)
Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H822-36. (PMID: 27521418)
Am Rev Respir Dis. 1979 Feb;119(2 Pt 2):101-6. (PMID: 426333)
J Biochem. 1988 Feb;103(2):274-80. (PMID: 3286628)
Heart Lung. 2012 Mar-Apr;41(2):137-45. (PMID: 22177761)
Ophthalmology. 2012 Sep;119(9):1832-43. (PMID: 22633114)
Muscle Nerve. 2016 Jun;54(1):71-8. (PMID: 26616495)
BMC Genet. 2018 Aug 8;19(1):55. (PMID: 30089464)
Eur Heart J. 1996 Aug;17(8):1239-50. (PMID: 8869866)
Nutr Diabetes. 2012 Sep 17;2:e46. (PMID: 23446662)
Circ Res. 1979 Apr;44(4):503-12. (PMID: 428047)
Biochem Biophys Res Commun. 2016 Oct 21;479(3):602-606. (PMID: 27680313)
Science. 2001 Nov 23;294(5547):1704-8. (PMID: 11679633)
Braz J Phys Ther. 2014 Jan-Feb;18(1):1-8. (PMID: 24675907)
Cell Growth Differ. 1992 Jun;3(6):335-45. (PMID: 1419896)
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19090-5. (PMID: 20956306)
Biochim Biophys Acta. 2016 Dec;1862(12):2259-2269. (PMID: 27421947)
Physiol Res. 2017 Sep 26;66(Suppl 3):S357-S365. (PMID: 28948820)
Nat Genet. 2004 Feb;36(2):178-82. (PMID: 14745449)
Acta Physiol (Oxf). 2006 Sep;188(1):3-13. (PMID: 16911248)
Nat Commun. 2017 Nov 23;8(1):1725. (PMID: 29170369)
Exp Cell Res. 2010 Jul 1;316(11):1856-70. (PMID: 20206623)
Trends Endocrinol Metab. 2016 May;27(5):335-347. (PMID: 27025788)
J Cachexia Sarcopenia Muscle. 2015 Dec;6(4):381-90. (PMID: 26674018)
J Biol Chem. 2007 Sep 7;282(36):26409-17. (PMID: 17616530)
J Biol Chem. 1984 Jun 10;259(11):7163-8. (PMID: 6233279)
J Biol Chem. 1982 May 10;257(9):4688-90. (PMID: 7068657)
Cardiovasc Res. 2002 Apr;54(1):95-104. (PMID: 12062366)
Am J Physiol. 1993 May;264(5 Pt 1):C1085-95. (PMID: 8388631)
Circ J. 2009 Feb;73(2):208-13. (PMID: 19110504)
Int J Biol Macromol. 2018 Dec;120(Pt A):310-317. (PMID: 30144543)
Cell Physiol Biochem. 2014;34(2):333-45. (PMID: 25060722)
Bioessays. 2002 Nov;24(11):1023-9. (PMID: 12386933)
J Cachexia Sarcopenia Muscle. 2018 Jun;9(3):547-556. (PMID: 29573220)
Biochem Pharmacol. 2014 Jul 1;90(1):88-95. (PMID: 24792439)
Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E1-E31. (PMID: 27166285)
Biochem J. 2011 Mar 15;434(3):365-81. (PMID: 21348856)
J Lipid Res. 2013 Oct;54(10):2636-46. (PMID: 23918045)
Respir Physiol Neurobiol. 2016 Jun;226:137-46. (PMID: 26467183)
Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E703-11. (PMID: 25159324)
Int J Biochem. 1979;10(5):423-6. (PMID: 478104)
J Pharmacol Exp Ther. 2015 Apr;353(1):159-68. (PMID: 25678535)
BMC Genomics. 2017 May 25;18(1):411. (PMID: 28545403)
Cell Calcium. 2003 Mar;33(3):163-74. (PMID: 12600803)
FEBS J. 2013 Sep;280(17):4131-48. (PMID: 23663276)
J Biol Chem. 2007 Jan 19;282(3):1650-7. (PMID: 17121852)
Curr Opin Lipidol. 2008 Jun;19(3):248-56. (PMID: 18460915)
J Physiol Pharmacol. 2006 Nov;57 Suppl 10:31-42. (PMID: 17242489)
Protein Cell. 2014 Mar;5(3):203-13. (PMID: 24633815)
Eur Respir J. 2012 Jun;39(6):1449-57. (PMID: 22034652)
Physiol Rev. 2003 Oct;83(4):1269-324. (PMID: 14506306)
J Appl Physiol (1985). 2016 Apr 1;120(7):733-42. (PMID: 26846552)
Int J Cardiol. 2008 Aug 29;128(3):326-35. (PMID: 17689734)
Grant Information:: R01 HL130318 United States HL NHLBI NIH HHS
Contributed Indexing:: Keywords: Heart failure; Respiratory muscle; Transcriptome
Substance Nomenclature:: 0 (Muscle Proteins)
Entry Date(s):: Date Created: 20201217 Date Completed: 20210127 Latest Revision: 20230530
Update Code:: 20240105
PubMed Central ID:: PMC10226370
DOI:: 10.1016/j.gene.2020.145356
PMID:: 33333219
: Czasopismo naukowe

Full Text Finder

The diaphragm is the main inspiratory muscle, and the chronic phase post-myocardial infarction (MI) is characterized by diaphragm morphological, contractile, and metabolic abnormalities. However, the mechanisms of diaphragm weakness are not fully understood. In the current study, we aimed to identify the transcriptome changes associated with diaphragm abnormalities in the chronic stage MI. We ligated the left coronary artery to cause MI in rats and performed RNA-sequencing (RNA-Seq) in diaphragm samples 16 weeks post-surgery. The sham group underwent thoracotomy and pericardiotomy but no artery ligation. We identified 112 differentially expressed genes (DEGs) out of a total of 9664 genes. Myocardial infarction upregulated and downregulated 42 and 70 genes, respectively. Analysis of DEGs in the framework of skeletal muscle-specific biological networks suggest remodeling in the neuromuscular junction, extracellular matrix, sarcomere, cytoskeleton, and changes in metabolism and iron homeostasis. Overall, the data are consistent with pathological remodeling of the diaphragm and reveal potential biological targets to prevent diaphragm weakness in the chronic stage MI.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

Informacja