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Tytuł:
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Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells.
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Autorzy:
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Lee KH; Daegu Haany University, Gyeongsan, 38610, Republic of Korea.
Lee JP; Jincostech Corp., Siheung, 15083, Republic of Korea.
Kim W; Daegu Haany University, Gyeongsan, 38610, Republic of Korea. .
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Źródło:
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Scientific reports [Sci Rep] 2020 Dec 17; Vol. 10 (1), pp. 22132. Date of Electronic Publication: 2020 Dec 17.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: London : Nature Publishing Group, copyright 2011-
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MeSH Terms:
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Agrimonia/*chemistry
Complex Mixtures/*pharmacology
Glycyrrhiza/*chemistry
Houttuynia/*chemistry
Paeonia/*chemistry
Phellodendron/*chemistry
Plant Extracts/*pharmacology
Skin/*drug effects
Cell Death/drug effects ; Cells, Cultured ; Cellular Senescence/drug effects ; Collagen/metabolism ; Complex Mixtures/chemistry ; Cytokines/metabolism ; Dermis/cytology ; Dermis/drug effects ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Filaggrin Proteins ; Gene Expression Profiling ; Humans ; Inflammation Mediators/metabolism ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Plant Extracts/chemistry ; Skin/cytology
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References:
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Substance Nomenclature:
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0 (Complex Mixtures)
0 (Cytokines)
0 (FLG protein, human)
0 (Filaggrin Proteins)
0 (Inflammation Mediators)
0 (Plant Extracts)
9007-34-5 (Collagen)
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Entry Date(s):
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Date Created: 20201218 Date Completed: 20210510 Latest Revision: 20211204
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Update Code:
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20240105
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PubMed Central ID:
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PMC7746697
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DOI:
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10.1038/s41598-020-79301-2
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PMID:
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33335246
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Active ingredients derived from natural sources are widely utilized in many industries. Cosmetic active ingredients are largely derived from various plants. In this study, we examined whether a mixture of plant extracts obtained from agrimonia, houttuynia, licorice, peony, and phellodendron (hereafter AHLPP), which are well-known for their effects on skin, could affect skin barrier function, inflammation, and aging in human skin cells. We also determined whether AHLPP extracts sterilized using γ-irradiation (to avoid preservatives) retained their skin cell regulating activity. The AHLPP mixture could downregulate representative pro-inflammatory cytokines including IL 1-β and IL 7. Procollagen peptide synthesis was also increased by AHLPP treatment along with mRNA upregulation of barrier proteins such as filaggrin and desmoplakin. The AHLPP mixture showed an anti-aging effect by significantly upregulating telomerase activity in human keratinocytes. We further observed TERT upregulation and CDKN1B downregulation, implying a weakening of pro-aging signal transduction. Co-cultivation of a hydrogel polymer containing the AHLPP mixture with human skin cells showed an alteration in skin-significant genes such as FLG, which encodes filaggrin. Thus, the AHLPP mixture with or without γ-irradiation can be utilized for skin protection as it alters the expression of some significant genes in human skin cells.