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Tytuł:
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Na 2 S 2 O 8 Nanoparticles Trigger Antitumor Immunotherapy through Reactive Oxygen Species Storm and Surge of Tumor Osmolarity.
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Autorzy:
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Liu Y; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
Zhen W; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
Wang Y; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.
Song S; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
Zhang H; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.; Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
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Źródło:
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Journal of the American Chemical Society [J Am Chem Soc] 2020 Dec 30; Vol. 142 (52), pp. 21751-21757. Date of Electronic Publication: 2020 Dec 18.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Washington, DC : American Chemical Society
Original Publication: Easton, Pa. [etc.]
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MeSH Terms:
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Immunotherapy/*methods
Nanoparticles/*chemistry
Reactive Oxygen Species/*metabolism
Sodium Compounds/*chemistry
Sodium Compounds/*pharmacology
Sulfates/*chemistry
Sulfates/*pharmacology
Cell Line, Tumor ; Endocytosis/drug effects ; Humans ; Hydrogen-Ion Concentration ; Osmolar Concentration ; Phospholipids/chemistry ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
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Substance Nomenclature:
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0 (Phospholipids)
0 (Reactive Oxygen Species)
0 (Sodium Compounds)
0 (Sulfates)
J49FYF16JE (sodium persulfate)
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Entry Date(s):
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Date Created: 20201218 Date Completed: 20210416 Latest Revision: 20210416
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Update Code:
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20240105
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DOI:
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10.1021/jacs.0c09482
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PMID:
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33337859
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Although more attention has been attracted to the therapy based on reactive oxygen species (ROS) for tumor therapy in recent years, such as photodynamic therapy and chemodynamic therapy, the limited ROS production rate leads to their poor treatment effect owing to the relatively low content of O 2 and H 2 O 2 in tumor microenvironments, confined light penetration depth, strict Fenton reaction conditions (pH 3-4), and so on. Therefore, it is urgent to explore the new agents with highly efficient ROS generation capacity. Herein, we first prepared phospholipid coated Na 2 S 2 O 8 nanoparticles (PNSO NPs) as new ROS generation agents for in situ generating Na + and S 2 O 8 2- through gradual degradation, which can then be changed to toxic • SO 4 - (a novel reported ROS) and • OH regardless of the amount of H 2 O 2 and pH value in the tumor microenvironment (TME). As the generation of a large amount of Na + , PNSO NPs can bypass the ion transport rules of cells through endocytosis to deliver large amounts of Na + into the cells, resulting in a surge of osmolarity and rapid cell rupture and lysis. Osmotic pressure induced by PNSO NPs will further lead to an unusual manner of cell death: caspase-1-related pyroptosis. Moreover, all of above effects will cause high immunogenic cell death, regulate the immunosuppressed TME, and then activate systemic antitumor immune responses to combat tumor metastasis and recurrence. We believe PNSO NPs will be new and potential ROS generation agents, and this work will broaden the thinking of the exploring of new antitumor nanodrugs.