Late-onset myocardial infarction and autoimmune haemolytic anaemia in a COVID-19 patient without respiratory symptoms, concomitant with a paradoxical increase in inflammatory markers: a case report.

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Abstrakt

Tytuł:: Late-onset myocardial infarction and autoimmune haemolytic anaemia in a COVID-19 patient without respiratory symptoms, concomitant with a paradoxical increase in inflammatory markers: a case report.
Autorzy:: Pelle MC; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. .
Tassone B; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Ricchio M; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Mazzitelli M; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Davoli C; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Procopio G; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Cancelliere A; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
La Gamba V; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Lio E; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Matera G; Department of Health Sciences, Unit of Clinical Microbiology, University 'Magna Graecia', Catanzaro, Italy.
Quirino A; Department of Health Sciences, Unit of Clinical Microbiology, University 'Magna Graecia', Catanzaro, Italy.
Barreca GS; 'Mater Domini' teaching hospital, Unit of Clinical Microbiology, Catanzaro, Italy.
Trecarichi EM; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Torti C; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Corporate Authors:: IDTM UMG COVID-19 Group
Źródło:: Journal of medical case reports [J Med Case Rep] 2020 Dec 18; Vol. 14 (1), pp. 246. Date of Electronic Publication: 2020 Dec 18.
Typ publikacji:: Case Reports; Journal Article
Język:: English
Imprint Name(s):: Original Publication: [London] : BioMed Central, [2007-
MeSH Terms:: Asymptomatic Infections*
Anemia, Hemolytic, Autoimmune/*blood
C-Reactive Protein/*immunology
COVID-19/*blood
Interleukin-6/*immunology
ST Elevation Myocardial Infarction/*diagnosis
Aged, 80 and over ; Anemia, Hemolytic, Autoimmune/drug therapy ; Anemia, Hemolytic, Autoimmune/etiology ; Anti-Bacterial Agents/therapeutic use ; Azithromycin/therapeutic use ; COVID-19/complications ; COVID-19/immunology ; Coombs Test ; Electrocardiography ; Enzyme Inhibitors/therapeutic use ; Female ; Glucocorticoids/therapeutic use ; Humans ; Hydroxychloroquine/therapeutic use ; Platelet Aggregation Inhibitors/therapeutic use ; Prednisolone/therapeutic use ; SARS-CoV-2 ; ST Elevation Myocardial Infarction/drug therapy ; ST Elevation Myocardial Infarction/etiology ; COVID-19 Drug Treatment
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JAMA. 2020 Mar 17;323(11):1061-1069. (PMID: 32031570)
Lancet. 2020 Mar 28;395(10229):1054-1062. (PMID: 32171076)
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Contributed Indexing:: Investigator: MC Pelle; B Tassone; M Ricchio; M Mazzitelli; C Davoli; G Procopio; A Cancelliere; V La Gamba; E Lio; G Matera; A Quirino; GS Barreca; EM Trecarichi; C Torti; E Arrighi; B Bertucci; MT Busceti; C Carallo; FS Costanzo; A De Francesco; P Fusco; L Gallo; A Giancotti; A Giudice; G Greco; D Laganà; A Lamberti; MC Liberto; R Lionello; N Marascio; G Marrazzo; M Petullà; G Perri; V Scaglione; F Serapide; C Indolfi; F Longhini; A Bruni; E Garofalo
Keywords: AIHA; Anaemia; COVID-19; Cardiovascular disease; IL-6; Inflammation
Substance Nomenclature:: 0 (Anti-Bacterial Agents)
0 (Enzyme Inhibitors)
0 (Glucocorticoids)
0 (Interleukin-6)
0 (Platelet Aggregation Inhibitors)
4QWG6N8QKH (Hydroxychloroquine)
83905-01-5 (Azithromycin)
9007-41-4 (C-Reactive Protein)
9PHQ9Y1OLM (Prednisolone)
Entry Date(s):: Date Created: 20201219 Date Completed: 20210101 Latest Revision: 20231110
Update Code:: 20240105
PubMed Central ID:: PMC7746982
DOI:: 10.1186/s13256-020-02595-3
PMID:: 33339534
: Czasopismo naukowe

Pełny tekst

Background: In December 2019, a new coronavirus (named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) spread from China, causing a pandemic in a very short time. The main clinical presentation of SARS-CoV-2 infection (COVID-19, coronavirus disease-2019) is pneumonia, but several cardiovascular complications may also occur (e.g., acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure and cardiogenic shock). Direct or indirect mechanisms induced by SARS-CoV-2 could be implicated in the pathogenesis of these events.
Case Presentation: We report herein the third case of COVID-19 autoimmune haemolytic anaemia (AIHA) reported so far, which occurredwithout any other possible explanations in a Caucasian patient. The patient also suffered from ST-elevation myocardial injury.
Conclusions: Both complications occurred quite late after COVID-19 diagnosis and were probably precipitated by systemic inflammation, as indicated by a significant delayed increase in inflammatory markers, including interleukin-6 (IL-6).

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